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Copyright@Beijing University of Chemical Technology Address: 15 Beisanhuan East Road, Chaoyang District, Beijing, China Zip code：100029 Email：news@buct.edu.cn |
IntroductionYao Qingxin, male, associate professor, Beijing University of Chemical Technology. In recent years, the main research work has been carried out in the field of in situ supramolecular assembly to construct functional nanomaterials, and certain innovative achievements have been made in construction of in situ supramolecular nanomaterials, which were used for targeted drug delivery. (1) Using the abnormal physiological conditions of the lesion, especially the high expression of enzymes and reactive oxygen species, the functional biomaterials with lesion selectivity were constructed by in situ supramolecular assembly technology; (2) Elucidating the micro-dynamic structure of in-situ constructed biomaterials and their interactions with biomacromolecules or suborganelles, providing a basis for the molecular design of materials; (3) Explore the carrier function of in-situ construction of biomaterials, achieve targeted delivery and controllable activation of drugs, and demonstrate safe and effective tumor diagnosis and treatment strategies. As the first or corresponding author, we have published more than 11 research papers including Nature Communications, Advanced Materials, ACS Nano, Biomaterials, etc., and obtained 7 national invention patents. We are supported by the National Natural Science Foundation of China, the Beijing Natural Science Foundation, and the China Postdoctoral Science Fund. EducationWork ExperienceSocial PositionSocial ActivitiesResearch1. In situ supramolecular self-assembly 2. Drug delivery and controlled release TeachingPostgraduatesFundingNational Natural Science Foundation of China 2020-01 to 2022-12 Beijing Natural Science Foundation 2020-01 to 2021-12 CAS Key Research Program of Frontier Sciences 2019-09 to 2024-09 China Postdoctoral Science Foundation 2019-06 to 2020-05 Vertical ProjectHorizontal ProjectPublications1. Xiaoqian Hu#, Qingxin Yao#, Xiaobo Wu#, Jiali Chen, Ruijia Zhang, Yan Zhao and Yuan Gao*. In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation. Nature Communications, 2025, Accept. 2. Qingxin Yao#, Ziyang Wu#, Jiaan Li, Xiaoqian Hu, Hanlin Xu, Xingyu Jiang*, Yuan Gao*. Reactive oxygen species-instructed supramolecular assemblies enable bioorthogonally activatable protein degradation for pancreatic cancer. Journal of the American Chemical Society, 2025, 147, 18208−18218. 3. Qingxin Yao#, Feng Lin#, Chenghao Lu, Ruijia Zhang, Hanlin Xu, Xiaoqian Hu, Ziyang Wu, Yuan Gao*, Peng R. Chen*. A dual-mechanism targeted bioorthogonal prodrug therapy. Bioconjugate Chemistry, 2023, 34, 12, 2255-2262. 4. Jie Zhao, Xiaobo Wu, Jiali Chen, Chengling Wu, Ruijia Zhang, Qingxin Yao*, Jianjun Xie*, Yuan Gao*. In situ supramolecular self-assembly for alleviating multidrug resistancein cancer. Supramolecular Materials, 2023, 2, 100033. 5. 吴小波, 赵婕, 高远, 姚庆鑫*, 谢建军*. 靶向递送蛋白水解靶向嵌合体在癌症治疗中的研究进展. 生物工程学报, 2023, 39, 3628-3643. 6. Chengling Wu#, Jingyu Xie#, Qingxin Yao#, Yilin Song, Gucheng Yang, Jie Zhao, Ruijia Zhang, Ting Wang, Xingyu Jiang, Xinxia Cai*, Yuan Gao*. Intrahippocampal supramolecular assemblies directed bioorthogonal liberation of neurotransmitters to suppress seizures in freely moving mice. Advanced Materials. 2024, 2314310. 7. Jialei Song, Chengling Wu, Yan Zhao, Min Yang, Qingxin Yao,* Yuan Gao*. Bioorthogonal disassembly of tetrazine bearing supramolecular assemblies inside living cells. Small, 2022, 18, 2104772. 8. Qingxin Yao, Shuo Gao, Chengling Wu, Ting Lin*, Yuan Gao*. Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance. Biomaterials, 2021, 277, 121119. 9. Qingxin Yao, Chengling Wu, Jiali Chen, Yan Zhao, Yuan Gao*. Enzyme-instructed supramolecular assemblies promote intracellular boron accumulation for boron neutron capture therapy. Nanotechnology, 2021, 32, 435602. 10. Qingxin Yao#, Guangqi Wu#, Hao Hao#, Hua Lu*, Yuan Gao*. Redox-mediated reversible supramolecular assemblies driven by switch and interplay of peptide secondary structures. Biomacromolecules, 2021, 22, 2563-2572. 11. Qingxin Yao#, Chenlei Wang#, Meifang Fu, Luru Dai*, Junbai Li*, and Yuan Gao*. Dynamic detection of active enzyme instructed supramolecular assemblies in situ via super-resolution microscopy. ACS Nano, 2020, 14, 4882-4889. 12. Qingxin Yao, Zhentao Huang, Dongdong Liu, Jiali Chen, Yuan Gao*. Enzyme-instructed supramolecular self-assembly with anticancer activity. Advanced Materials, 2019, 31, 1804814. 13. Qingxin Yao, Feng Lin, Xinyuan Fan, Yanpu Wang, Ye Liu, Zhaofei Liu, Xingyu Jiang, Peng R. Chen*, Yuan Gao*. Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. Nature Communications, 2018, 9, 5032. 14. Qingxin Yao#, Qiang Bao#, Xinming Li, Hui Wang, Zhenyu Yang, Xinghua Shi*, Yuan Gao*, Bing Xu. Determination of the packing model of a supramolecular nanofiber via mass-per-length measurement and de novo simulation. Nanoscale, 2018, 10, 3990. AwardsPatentHonor RewardAdmissions Information |