Introduction
She primarily focuses on the study of stimulus-responsive biomaterials and molecular probes for cancer diagnosis and treatment, and has achieved a series of significant research findings in the fields of optical imaging as well as the design and application of cancer diagnostic and therapeutic probes. To date, she has published 43 academic papers in prestigious international journals in the fields of chemistry, materials science and biomedicine with a h index of 19. Notably, she served as the first or corresponding author in renowned international journals including Angewandte Chemie International Edition, ACS Nano, Nano Letters, Small Methods, Chemical Science and Advanced Drug Delivery Reviews. Furthermore, she has successfully applied for and obtained four national invention patents.
Research
(1) In vivo imaging and molecular measurement: Accurate monitoring of the temporal and spatial distribution, function, and interaction mode of disease-related marker molecules in deep tissues are a crucial prerequisite for further elucidating the pathogenic mechanism, diagnosing and treating diseases, as well as predicting treatment efficacy. The probe enables exploration and precise description of the in vivo spatial and temporal distribution of molecules while establishing the structure-activity relationship between them and the occurrence and progression of diseases.
(2) The novel technology for disease diagnosis and treatment: By employing biological molecular response probes for quantitative detection and dynamic monitoring information on early markers in disease diagnosis and treatment, this approach reveals both the underlying mechanisms driving disease development as well as changes occurring during diagnosis/treatment processes. It provides a new avenue towards efficient disease diagnosis and treatment.
Teaching
Analytical chemistry New techniques for chemical and biological imaging
Funding
1. National Natural Science Foundation Committee, Youth Fund, as PI, in research.
2. Beijing Natural Science Foundation Committee, General Program, as PI, in research.
3. China Postdoctoral Science Foundation, Special Funding (Pre-Station), as PI, concluded.
4. China Postdoctoral Science Foundation, General Program, as PI, concluded.
Publications
1. Su, L.#; Zhu, K.#; Ge, X.#; Wu, Y.*; Zhang, J.; Wang, G.; Liu, D.; Chen, L.*; Li, Q.; Chen, J.; Song, J.*, X-ray Activated Nanoprodrug for Visualization of Cortical Microvascular Alterations and NIR-II Image-Guided Chemo-Radiotherapy of Glioblastoma, Nano letters 2024, DOI: 10.1021/acs.nanolett.4c00223.
2. Mo, C.; Zhang, W.; Zhu, K.; Du, Y.; Huang, W.*; Wu, Y.*; Song, J.*, Advances in Injectable Hydrogels Based on Diverse Gelation Methods for Biomedical Imaging, Small Methods 2024, 10.1002/smtd.202400076.
3. Liu, X.#; Wang, J.#; Wu, Y.*; Wu, M.*; Song, J.*, Ultrasound Activated Probe for Disease Imaging and Therapy In-Vivo. Advanced Drug Delivery Reviews 2024, 205, 115158.
4. Wu, Y.; Su, L.; Yuan, M.; Chen, T.; Ye, J.; Jiang, Y.; Song, J.*; Yang, H.*, In Vivo X-ray Triggered Catalysis of H2 Generation for Cancer Synergistic Gas Radiotherapy. Angewandte Chemie International Edition 2021, 60 (23), 12868-12875.
5. Wu, Y.; Yuan, M.; Song, J.*; Chen, X.*; Yang, H.*, Hydrogen Gas from Inflammation Treatment to Cancer Therapy. ACS Nano 2019, 13 (8), 8505-8511.
6. Wu, Y.; Zhu, K.; Zhang, X.; Du, W.; Song, J.; Yang, H., Emerging Plasmonic Nanoparticles and Their Assemblies for Cancer Radiotherapy. Advanced Drug Delivery Reviews 2023, 194, 114710.
7. Wu, Y.; Guo, T.; Qiu, Y.; Lin, Y.; Yao, Y.; Lian, W.; Lin, L.; Song, J.*; Yang, H., An Inorganic Prodrug, Tellurium Nanowires with Enhanced ROS Generation and GSH Depletion for Selective Cancer Therapy. Chemical Science 2019, 10 (29), 7068-7075.
8. Chen, Z.; Su, L.; Wu, Y.; Liu, J.; Wu, R.; Li, Q.; Wang, C.; Liu, L.; Song, J.*, Design and Synthesis of a Small Molecular NIR-II Chemiluminescence Probe for In Vivo-activated H2S imaging. Proceedings of the National Academy of Sciences of the United States of America 2023, 120 (8), e2205186120.
9. Liu, L.; Wu, Y.; Ye, J.; Fu, Q.; Su, L.; Wu, Z.; Feng, J.; Chen, Z.; Song, J.*, Synthesis of Magnesium Nanoparticle for NIR-II-photoacoustic-imaging-guided Synergistic Burst-like and H2 Cancer Therapy. Chem 2022, 8 (11), 2990-3007.
10. Zhang, X.#; Li, Z. W.#; Wu, Y.; Ge, X.; Su, L.; Feng, H.; Wu, Z.; Yang, H.; Song, J.*, Highly Controlled Janus Organic-Inorganic Nanocomposite as a Versatile Photoacoustic Platform. Angewandte Chemie International Edition 2022, 60 (32), 17647-17653.
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