IntroductionDr. Shihui Wang, Associate Professor, received her PhD degree in Engineering from Tianjin University in 2012, then taught at the School of Life Science and Technology of Beijing University of Chemical Technology, and spent one year in Lakehead University, Canada in 2015-2016 as an exchange visit. Dr. Shihui Wang has long been committed to the research in the field of biomedicine, mainly engaged in molecular diagnosis, bioinformatics, cancer prevention and control, nano-loaded drugs, traditional Chinese medicine modification, food science and other fields of research. As the project leader and backbone member, he has participated in a total of 10 key projects of the National Natural Science Foundation, surface projects, youth funds, etc., and published more than 40 papers included in SCI, of which a total of 35 were published and communicated, and 5 were conference papers. Her awards include Academic Newcomer Award of the Ministry of Education, Excellent Doctoral Thesis Fund of Tianjin University, Outstanding Student of Tianjin University, Outstanding Communist Party Member, etc. EducationWork ExperienceSocial PositionSocial ActivitiesResearch1. Molecular diagnosis
2. Cancer prevention
3. Nanomaterials
4. Chinese medicine modification
5. Food science TeachingEnzyme and biocatalysis PostgraduatesFundingVertical ProjectHorizontal ProjectPublications1.Susu Liu, Yuan Liu, Luanying He, Fei He, Na Wang, Jinting Peng, Changyuan Yu, and Shihui Wang, Synergetic HepG2 cells suppression efficacy of Tripterygium wilfordii and Scutellaria barbata through EGFR/PI3K/Akt pathway. Pharmacological Research - Modern Chinese Medicine, 2022. 4: p. 100130. 2.N. Wang, Y. Li, F. He, S. Liu, Y. Liu, J. Peng, J. Liu, C. Yu, and S. Wang, Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy. Pharmaceuticals (Basel, Switzerland), 2022. 15(9). 3.何飞, 刘园, 刘素素, 王娜, 宋海红, 熊国良, 卢建东, 喻长远, and 王诗卉, 雷公藤红素抑制Cd<sup>2+</sup>诱导的神经毒性. 生物工程学报, 2022. 38(9): p. 3443-3452. 4.王娜, 何飞, 郁宏伟, 何栾樱, 熊国良, 卢建东, 喻长远, and 王诗卉, 在cDNA文库构建中探究癌症病人血浆外泌体miRNA的特异性扩增. 生物工程学报, 2022. 38(6): p. 11. 5.刘园, 刘素素, 李璋龙, 陈嘉程, 宋海红, 喻长远, 刘佳蕙, and 王诗卉, 氧化石墨烯包封的酵母细胞对镉离子的吸附作用. 北京化工大学学报(自然科学版), 2023. 50(6): p. 38-46. 6.F. He, N. Wang, J. Li, L. He, Z. Yang, J. Lu, G. Xiong, C. Yu, and S. Wang, High affinity monoclonal antibody targeting Siglec-15 for cancer immunotherapy. J. Clin. Transl. Res., 2021. 7(6): p. 739-749. 7.Victoria Arantza León Anchustegui, Junhao Zhu, Luanying He, Ying Bi, Yiyang Dong, Jia-Hui Liu, and Shihui Wang, Coencapsulation of Carbon Dots and Gold Nanoparticles over Escherichia coli for Bacterium Assay by Surface-Enhanced Raman Scattering. ACS Applied Bio Materials, 2021. 4(1): p. 597-604. 8.Jia-Hui Liu, Junhao Zhu, Na Wang, Fei He, Luanying He, Haihong Song, Yiyang Dong, Li Zhang, and Shihui Wang, Quantitative detection of trace copper by using graphene oxide and x-ray fluorescence spectroscopy. NANO: Brief Reports and Reviews, 2021. 16(6): p. 2150066. 9.何栾樱, 林子淳, 卢建东, 熊国良, and 王诗卉, 基于灵芝双向固体发酵雷公藤减毒持效的研究. 北京化工大工学学报, 2021. 48(4): p. 48-56. 10.Luanying He, Yulin Chang, Junhao Zhu, Ying Bi, Wenlin An, Yiyang Dong, Jia-Hui Liu, and Shihui Wang, A cytoprotective graphene oxide-polyelectrolytes nanoshell for single-cell encapsulation. Front. Chem. Sci. Eng., 2020. 46. 11.Peili Yan, Youhong Su, Chengzhang Shang, Xiaofei Zhou, and Shihui Wang, The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation. Immunobiology, 2020: p. 151998. 12.宋海红、毕滢、何栾樱、闫培丽、安文林、喻长远、王诗卉, 雷公藤甲素与雷公藤红素对小胶质细胞炎症反应的影响机制. 北京化工大学学报(自然科学版), 2020. 47(05): p. 86-91. 13.Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia Hui Liu, and Shihui Wang, Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions. Toxicol Res-UK, 2019. 8: p. 908-917. 14.Yu Feng, Shuang Cai, Guoliang Xiong, Guanfei Zhang, Shi-Hui Wang, Xin Su, and Changyuan Yu, Sensitive Detection of DNA Lesions by Bulge Enhanced Highly Specific COLD-PCR. Anal Chem, 2017. 89(15): p. 8084-8091 15.Hai Peng Guo, Chao Yang Lin, Shi Hui Wang, Dean Jiang, Bing Song Zheng, Yun Liu, and Wen Sheng Qin, Characterization of a novel laccase-producing Bacillus sp. A4 and its application in Miscanthus degradation. Bioresources, 2017. 12(3): p. 4776-4794. 16.Junxiu Wang, Guoliang Xiong, Liang Ma, Shihui Wang, Xu Zhou, Lei Wang, Lehui Xiao, Xin Su, and Changyuan Yu, A dynamic sandwich assay on magnetic beads for selective detection of single-nucleotide mutations at room temperature. Biosens Bioelectron, 2017. 94: p. 305. 17.Yun Liu, Hua Zhou, Liuyang Wang, and Shihui Wang, Stability and catalytic properties of lipase immobilized on chitosan encapsulated magnetic nanoparticles cross-linked with genipin and glutaraldehyde. . Journal of Chemical Technology & Biotechnology, 2016. 91(5): p. 1359-1367. 18.Shihui Wang, Jenasia Jeyaseelan, Yun Liu, and Wensheng Qin, Characterization and optimization of amylase production in WangLB, a high amylase-producing strain of Bacillus. Appl Biochem Biotech, 2016. 180(1): p. 136-151. 19.Shihui Wang, Chaoyang Lin, Yun Liu, Zhicheng Shen, Jenasia Jeyaseelan, and Wensheng Qin, Characterization of a starch-hydrolyzing α-amylase produced by Aspergillus niger WLB42 mutated by ethyl methanesulfonate treatment. Int J Biochem Mol Biol, 2016. 7(1): p. 1-10. 20.Shihui Wang, Xianghe Meng, Hua Zhou, Yang Liu, Francesco Secundo, and Yun Liu, Enzyme stability and activity in non-aqueous reaction systems: a mini review. Catalysts, 2016. 6(32): p. 1-16. 21.Liu Yun, Zhou Hua, Liuyang Wang, Shihui Wang, and Lihai Fan, Improving Saccharomyces cerevisiae growth against lignocellulose-derived inhibitors as well as maximizing ethanol production by a combination proposal of γ-irradiation pretreatment with in situ detoxification. Chem Eng J, 2016. 287: p. 302-312. 22.Shihui Wang, Zhongshuai Lian, Liuyang Wang, Xiao Yang, and Yun Liu, Preliminary investigations on a polygalacturonase from Aspergillus fumigatus in Chinese Pu’er tea fermentation. Bioresources and Bioprocessing, 2015. 2(1): p. 1-13. 23.Yun Liu, Hua Zhou, Shihui Wang, Keqin Wang, and Xiaojun Su, Comparison of γ-irradiation with other pretreatments followed with simultaneous saccharification and fermentation on bioconversion of microcrystalline cellulose for bioethanol production. Bioresource Technol, 2015. 182: p. 289-295. 24.Yun Liu, Yang Liu, Shihui Wang, Shengzhao Dong, Ping Chang, and Zhaofeng Jiang, Structural characteristics of (−)-epigallocatechin-3-gallate inhibiting amyloid Aβ42 aggregation and remodeling amyloid fibers. RSC Adv, 2015. 5(77): p. 62402-62413. 25.Shihui Wang, Zeya Sun, Shengzhao Dong, Yang Liu, and Yun Liu, Molecular interactions between (−)-epigallocatechin gallate analogs and pancreatic lipase. PLoS ONE, 2014. 9(11): p. e111143. 26.Shihui Wang, Shengzhao Dong, Rui Zhang, Haoying Shao, and Yun Liu, Effects of proanthocyanidins on porcine pancreatic lipase: conformation, activity, kinetics and thermodynamics. Process Biochem, 2014. 49(2): p. 237-243. 27.王诗卉 and 刘云, 茶叶儿茶素抑制剂对胰脂肪酶构效关系的影响. 食品科学, 2013. 34(9): p. 104-107. 28.Shihui Wang, Fu-Feng Liu, Xiao-Yan Dong, and Yan Sun, Calorimetric and spectroscopic studies of the interactions between insulin and (-)-epigallocatechin-3-gallate. Biochem Eng J, 2012. 62(0): p. 70-78. 29.Shihui Wang, Xiao-Yan Dong, and Yan Sun, Thermodynamic analysis of the molecular interactions between amyloid β-protein fragments and (-)-epigallocatechin-3-gallate. J Phys Chem B, 2012. 116(20): p. 5803-5809. 30.Shihui Wang, Xiao-Yan Dong, and Yan Sun, Investigation into the mechanism of (-)-epigallocatechin-3-gallate-induced precipitation of insulin. Int J Biol Macromol, 2012. 50(5): p. 1229-1237. 31.Shihui Wang, Xiao-Yan Dong, and Yan Sun, Effect of (-)-epigallocatechin-3-gallate on human insulin fibrillation/aggregation kinetics. Biochem Eng J, 2012. 63(0): p. 38-49. 32.Shihui Wang, Fu-Feng Liu, Xiao-Yan Dong, and Yan Sun, Thermodynamic analysis of the molecular interactions between amyloid beta-peptide 42 and (-)-epigallocatechin-3-gallate. J Phys Chem B, 2010. 114(35): p. 11576-11583.
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