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Yang Zhao

Associate professor

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  • Email: yangzhao@mail.buct.edu.cn
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  • Introduction
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  • Publications
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  • Honor Reward
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Introduction

Zhao Yang, PhD

Associate Professor of Biomedical Engineering, Beijing University of Chemical Technology

Director, Research Center of Precision Medicine at Beijing University of Chemical Technology

Executive Editor, Innovative Medicines & Omics

Associate Editor, Microbes & Immunity

Research Field: Precision Oncology


Education

Work Experience

Social Position

Social Activities

Research

Our team have published over 70 papers across prestigious international journals including Cell Research, European Urology, Cancer Research, Clinical Cancer Research, Molecular Cancer, Journal of Experimental Medicine, Chemical Engineering Journal, EBioMedicine, and Critical Reviews in Food Science, with over 1000 citations. Additionally, we have published 8 professional books. We have led or participated in 14 projects funded by the Ministry of Science and Technology, the National Natural Science Foundation of China, and other national and local government agencies. Furthermore, we have applied for 23 Chinese invention patents with 12 granted. We have obtained the Shenzhen Science and Technology Progress Award (First Prize) in 2020 and the Outstanding Paper Award of Journal of Bioengineering in 2021.


Teaching

Undergraduate courses: Biostatistics, Bioinformatics, Biochemistry, Immunology, Genetic Engineering.

Graduate courses: Advanced Biochemistry, Molecular Biology, Stem Cell Engineering Therapeutics.


Postgraduates

Funding

1. Bladder Cancer Early Progression Key Molecular Events Visualization and Clinical Application, Major Research Program of National Natural Science Foundation of China, Grant No. 92359202, 2024.01-2026.12.

2. Mechanism Study of m5C Methyltransferase NSUN7 Driving Vascular Mimicry in the Malignant Progression of Prostate Cancer. Beijing University of Chemical Technology - Japan- China Friendship Hospital Biomedical Translational Engineering Research Center Joint General Project, Grant No. XK2023-21, 2023.01-2024.12.

3. Research on Nucleic Acid Delivery of Non-hepatic Targeting Nanozyme Carriers for Synergistic Catalytic Cancer Therapy. National Center for Biomedical Innovation and Technology Nuclear Acid Medicine Solve the Problem Technical Research Project, Grant No. NCTIB2022HS01016, 2022.11-2025.11.

4. Identification of Breast Cancer Stem Cell Subpopulations Based on Multi-omics Technology. Horizontal Project, Grant No. H2022438, 2022.10-2024.12.

5. Molecular Diagnostic Technology Innovation Research Center. Horizontal Project, Grant No. L2022023, 2022.08-2025.05.

6. Precision Medical Research Center. Horizontal Project, Grant No. L2020007, 2020.10-2023.09.

7. Visualization of Stem Cell-targeted Tumor Treatment Technology for Precision Diagnosis and Treatment of Tumors. Beijing-Tianjin-Hebei Basic Research Cooperation Special Project, Grant No. 19JCZDJC65800(Z), 2019.10-2022.09.

8. New Type CRISPR-Cas12a Structure and Function Research. Basic Scientific Research Business Fee of Central Universities, Grant No. buctrc201910, 2019.01-2021.08.

9. Screening of Methyltransferase KMT1A Inhibitors and Mechanism Study of Targeted Inhibition of Bladder Cancer Stem Cells. National Natural Science Foundation of China Youth Science Fund Project, Grant No. 81602644, 2017.01-2019.12.

10. Mutation Characteristics and Evolution Study of Bladder Urothelial Tissue Stem Cells. National Key R&D Program, Grant No. 2017YFA0105900, 2017.07-2021.12.


Vertical Project

Horizontal Project

Publications

1. Li C#, Wu S#, Yang Z#, Zhang X#, Zheng Q, Lin L, Niu Z, Li R, Cai Z, Li L*. Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells. Cell Res. 2017, 27(4):590-593.(SCI, 28.1, TOP) 

2.Su H#, Tao T#, Yang Z#, Kang X, Zhang X, Kang D, Wu S*, Li C*. Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression. Mol Cancer. 2019, 18(1):27.(SCI, 27.7, TOP)  

3. Yang Z#, Li C#, Fan Z#, Liu H#, Zhang X#, Cai Z#, Xu L, Luo J, Huang Y, He L, Liu C, Wu S*. Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells. Eur Urol. 2017, 71(1):8-12. (SCI, 25.3, TOP)

4. Yang Z*, Wu S, Cai Z, Li C*. Reply from Authors re: Xue-Ru Wu. Attention to Detail by Single-cell sequencing.. Eur Urol. 2017, 71(1):15-16. (SCI, 25.3, TOP)

5. Ye B#, Li C#, Yang Z#, Wang Y, Hao J, WangL, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y* and Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 211(12):2439-54. (SCI, 12.6, TOP)      

6. Yang Z#, Fu Sh i#, Li Yongchao, Liang Youfeng, Hao Mingxuan, Guo Rui, Yu Changyuan , Hussain Zahid, Zhang Jinku*, Wang Haifeng*. Exosome as non-invasive prognostic and diagnostic biomarker and nanovesicle for targeted therapy of non-small cell lung carcinoma. Chem Eng J. 2024, 480:148160. (SCI, 13.3, TOP)

7. Yang Z#, He L, Lin K, Zhang Y, Deng A, Liang Y, Li C*, Wen T*. The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells. Clin Cancer Res. 2017, 23(21):6673-6685.(SCI, 10.0, TOP) 

8. Li C#, Yang Z#, Du Y, Tang H, Chen J, Hu D, Fan Z*. BCMab1, a monoclonal antibody against aberrantly glycosylated integrin α3β1, has potent antitumor activity of bladder cancer in vivo. Clin Cancer Res. 2014, 20(15):4001-13. (SCI, 10.0, TOP)

9. Li C#, Du Y#, Yang Z#, He L, Wang Y, Hao L, Ding M, Yan R, Wang J, Fan Z*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 76(5):1273-83.(SCI, 12.5, TOP) 

10. Yang Z#, Zhang R#, Ge Y, Qin X, Kang X, Wang Y, Zhang X, Song C, Quan X, Wang H, Chen H*, Li C*. Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy. EBioMedicine. 2018, 35:198-203.(SCI, 9.7, TOP) 

11. Yang Z#, Shao Z#, Ouyang W, Ying L, Guo R, Hao M, Liang Y, Zhang W, Chen X, Chen R, Yu C, Prabahar K, Găman MA, Kord-Varkaneh H, Li H*, Zhao B*. The effect of green coffee extract supplementation on obesity indices: critical umbrella review of interventional meta-analyses. Crit Rev Food Sci Nutr. 2023, 1-9. (SCI, 7.3, TOP)

12. Yang Z#, Shahriari Marjan, Liang Y, Karmakar Bikash*, El-kott Attalla F, AlShehri Mohammed A, Negm Sally, Eltantawy Waleed. Biosynthesis of gold nanoparticles mediated by Curcuma longa extract: Evaluation of its catalytic activity for the degradation of environmental pollutants and study of anti-lung adenocarcinoma effects. J Sci-Adv Mater Dev. 2024, 9(2), 100709. (SCI, 6.7)

13. Sabeel Z, Liang Y, Hao M, Ying L, Guo R, Chen R, Li X, Yu C*, Yang Z*. A comprehensive review on antitumor properties of Angelica species and their antitumor responsible constituents, and underlying molecular mechanisms involved in tumor inhibition. Phytother Res. 2023, 37(5):2187-2211. (SCI, 6.1)

14. Yang Z#,*, Shi M#, Liang Y#, Zhang F#, Li C, Lu Y, Yin T, Wang Z, Li Y, Hao M, Guo R, Yang H, Lei G, Sun F, Zhang Y, Deng Z, Tian Y, Yu L, Bai C, Wang L, Wan C, Wang H*, Yang P*. Three‑dimensional chromatin landscapes in hepatocellular carcinoma associated with hepatitis B virus. J Gastroenterol. 2023, 59(2):119-137. (SCI, 6.9)

15. Wang L#, Deng A, Zhang Y, Liu S, Liang Y, Bai H, Cui D, Qiu Q, Shang X, Yang Z*, He X*, Wen T*. Efficient CRISPR-Cas9 mediated multiplex genome editing in yeasts. Biotechnol Biofuels. 2018, 11:277. (SCI, 6.1, TOP)

16. Yang Z#, Wang H#, Zhang N#, Xing T, Zhang W, Wang G*, Li C*, Yu C*. Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A-GATA3-STAT3 Circuit. Front Cell Dev Biol. 2020, 8:424.(SCI, 4.6) 

17. Naz F#, Shi M#, Sajid S, Yang Z*, Yu C*. Cancer stem cells: a major culprit of intra-tumor heterogeneity. Am J Cancer Res. 2021, 11(12):5782-5811.(SCI, 3.6) 


Awards

1. 2023, Silver Award, Best Diagnostic Project Nomination, Best New Basic Component Nomination at the International Genetically Engineered Machine Competition (iGEM) for Graduate Group

2. 2021, Outstanding Paper Award of Journal of Bioengineering

3. 2020, Shenzhen Science and Technology Progress Award (First Prize)


Patent

Honor Reward

Admissions Information