Feng Li头像

Feng Li

Professor

Research direction: Nucleic acid functional molecules

Non

Education: Dr.

10 Access

  • Email: fengli2022@mail.buct.edu.cn
  • Office : Huaxin Building
  • Introduction
  • Research
  • Teaching
  • Funding
  • Publications
  • Awards
  • Honor Reward
  • Admission

Introduction

Feng Li, is a Principal Investigator and doctoral supervisor at Beijing University of Chemical Technology, recipient of the National Excellent Youth Science Fund, high-level talent at Beijing University of Chemical Technology, and head of “Chemistry + Bioengineering” dual-degree program. Prof. Li obtained her B.S. degree from College of Chemistry and Chemical Engineering, Lanzhou University (2010), and Ph.D. degree from National Centre for Nanoscience and Nanotechnology, CAS (2015). In 2015, she joined the Department of Chemistry at Tsinghua University as a postdoc. From 2018 to 2022, she has worked as associate professor at School of Chemical Engineering and Technology, Tianjin University. Her current research interests are mainly the creation of intelligent nucleic acid nanomedicine and the development of gene therapy strategies. Focusing on “targeted and controllable release of nucleic acid drugs” and “green biosynthesis of nucleic acid drugs”, Prof. Li proposed new methods of nucleic acid molecule cascade assembly and enzymatic amplification, and expanded the application of nucleic acid nanomedicine in cell function intervention and the treatment of disease such as tumors and viral infections. In recent years, Prof. Li has published more than 50 papers, including Chem. Soc. Rev.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem.、Adv. Mater.、Nano Lett.、Nano Today、Acc. Mater. Res., etc., and has applied for 9 Chinese invention patens. The relevant research achievement has won the “Basic Research Achievement Award” of the Science and Technology Award of the Chinese Chemical Society. Prof. Li has hosted 8 foundation projects, such as National Natural Science Foundation of China (Excellent Youth Program, General Program and Youth Program). Prof. Li has edited the textbook “Nucleic Acid Functional Materials” in chief, co-authored the monograph “Synthetic Genomics” and the English monograph “Handbook of Chemical Biology of Nucleic Acids”, as well as the core course textbook “Chemical Biology Experiments” for the Chemistry “101 Project”. Prof. Li alos serves as the young editorial board member of Chinese Chem. Lett., and project review expert for NSFC.

Education

Work Experience

Social Position

Social Activities

Research

Nucleic acid chemistry

Nucleic acid drugs

Gene therapy

Teaching

Analytical Chemistry

Synthetic Genomics

Nucleic Acid Chemistry and Materials


Postgraduates

Funding

National Natural Science Foundation of China Excellent Youth Program

National Natural Science Foundation of China General Program

National Natural Science Foundation of Chin Youth Program

Vertical Project

Horizontal Project

Publications

1)        Yunhua Guo, Wenzhe Song, Yuhang Dong, Xuejun Wang*, Guangjun Nie, and Feng Li*, Nano Lett., 2024, DOI: 10.1021/acs.nanolett.3c04510

2)        Yuhang Dong,# Yunhua Guo,# Wenzhe Song,# Guangjun Nie,* and Feng Li*, Functional Integration of DNA and Peptide-Based Supramolecular Nanoassemblies for Cancer Therapy, Acc. Mater. Res. 2023, 4, 892-905.

3)        Feng Li+, Yiye Li+, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu*, Guangjun Nie*. Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine Affect Cellular Energy Metabolism. Angew. Chem. Int. Ed., 2018, 9, 2377-2382.

4)        Feng Li+* ,Xiaohui Ding+, Zhaoyue Lv, Jing Li, Dayong Yang*,  A DNA-polymer hybrid nanocomplex based bi-adjuvant vaccine for tumor immunotherapy, Nano Today, 2024, 54, 102061.

5)        Feng Li+, Jianpu Tang+, Jinhui Geng, Dan Luo, Dayong Yang*. Polymeric DNA Hydrogel: Design, Synthesisand Applications.

6)        Feng Li+, Wenting Yu+, Jiaojiao Zhang+, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang*, Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery. Nat. Commun., 2021, 12, 1138.

7)        Feng Li+, Yujie Liu+, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang*,Dynamic assembly of DNA nanostructures in living cells for mitochondrial interference.J. Am. Chem. Soc., 2022, 144, 4667-4677.

8)        Feng Li, Tianyu Li, Chenxing Sun, Jiahao Xia, Yang Jiao, and Huaping Xu*. Selenium-Doped Carbon Quantum Dots (Se-CQDs) for Free Radical Scavenging. Angew. Chem. Int. Ed.,2017, 129, 10042-10046.

9)        Feng Li+, Zhaoyue Lv+, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, and Dayong Yang*, Supramolecular self-assembled DNA nanosystem for synergistic chemical and gene regulations on cancer cells, Angew. Chem. Int. Ed., 2021, 60, 25557-25566.

10)     Feng Li+, Nachuan Song+, Yuhang Dong, Shuai Li, Linghui Li, Yujie Liu, Zhemian Li, Dayong Yang*. A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy, Angew. Chem. Int. Ed., 2022, 61, e202116569

11)     Feng Li+, Shuai Li+, Xiaocui Guo, Yuhang Dong, Chi Yao, Yangping Liu, Yuguang Song, Xiaoli Tan, Lizeng Gao, Dayong Yang*. Chiral carbon dots mimicking topoisomerase I to enantioselectively mediate topological rearrangement of supercoiled DNA. Angew. Chem. Int. Ed., 2020, 27, 11087-11092.

12)     Feng Li+, Yiye Li+, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu*, Guangjun Nie*. Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine Affect Cellular Energy Metabolism. Angew. Chem. Int. Ed., 2018, 9, 2377-2382.

13)     Jing Li, Jingping Wang, Ling Chen, Yuhang Dong, Haonan Chen, Guangjun Nie, Feng Li*. Self-Assembly of DNA Molecules at Bio-Interfaces and Their Emerging Applications for Biomedicines. Nano Res., 2023, 12，13014-13028.

14)     Feng Li+, Xiaolei Sun+, Jing Yang+, Jin Ren+, Mengxue Huang, Shengqi Wang*, Dayong Yang*. A Thermal and Enzymatic Dual-Stimuli Responsive DNA-Based Nanomachine for Controlled mRNA Delivery. Adv. Sci., 2023, 10, 2204905.

15)     Nachuan Song+, Shuai Li+, Zhaoyue Lv+, Xiaohui Ding, Feng Li*, Dayong Yang*. Engineering CRISPR/Cas-based nanosystems for therapeutics, diagnosis and bioimaging. Chinese Chem. Lett., 2023, 108134.

16)     Feng Li, Shuai Li, Dayong Yang*, Gene-Like Precise Construction of Functional DNA Materials. In: Sugimoto, N. (eds) Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. 2022, DOI:10.1007/978-981-16-1313-5_98-1.

17)     Yuhang Dong+, Feng Li+, Zhaoyue Lv, Shuai Li, Meihe Yuan, Nachuan Song, Jinqiao Liu, Dayong Yang*. Lysosome Interference Enabled by Proton-Driven Dynamic Assembly of DNA Nanoframeworks inside Cells.Angew. Chem. Int. Ed., 2022, 61, e202207770.

18)     Feng Li, Wei Cao, Lu Wang, and Huaping Xu*. Near-Infrared Light Stimuli-responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-containing Block Polymer and Cisplatin for Cancer Treatment. Biomaterials, 2017, 133, 208-218.

19)     Huaixin Zhao+, Zhili Zhang+, Duo Zuo+, Linghui Li, Feng Li*, and Dayong Yang*, A synergistic DNA-     polydopamine-MnO2 nanocomplex for near-infrared light powered DNAzyme-mediated gene therapy. Nano Lett., 2021, 21, 5477.

20)     Huaixin Zhao+, Linghui Li+, Feng Li*, Chunxia Liu, Mengxue Huang, Jiao Gao, Xinhua Ruan, Dayong Yang*, An energy stored DNA-based nanocomplex for laser-free photodynamic therapy. Adv. Mater.2022,34,2109920.

21)     Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*. Gene Circuit Compartment on Nano-interface Facilitates Cascade Gene Expression. J. Am. Chem. Soc. 2019, 141, 19171-19177.

22)     Xiaocui Guo+,Feng Li+, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, and Dayong Yang*. Construction of Organelle-like Architecture via Dynamic DNA Assembly in Living Cells. Angew. Chem. Int. Ed. 2020, 59, 20651-20658.


Awards

Patent

Honor Reward

Admissions Information