IntroductionDr. Asso. Prof. Ning Chen.(chenning@mail.buct.edu.cn) Majored in Organic chemistry. 2002-2006, BSc from Southwest University, Chongqing, China 2006-2011, PhD with Prof. Jiaxi Xu, Beijing University of Chemical Technology, Beijing, China 2015-2016, Post-Doc with Prof. Chao-Jun Li, McGill University, Montreal, Canada. EducationWork ExperienceSocial PositionSocial ActivitiesResearch1) Organic Synthesis and Synthetic Methodologies. 2) Pharmaceutical Synthesis Teachingorganic chemistry organic spectroscopic analysis PostgraduatesFundingVertical ProjectHorizontal ProjectPublications1. Wang, Jianwei; Zhang, Zhiqian; Li, Chengrui; Wang, Miao; Tan, Jiajing; Du, Hongguang; Chen, Ning. Sunlight-induced Three-Component Synthesis of α-Aminoketones: A Green and Sustainable Pathway Through EDA Complex. Org. Chem. Front. 2024, 11, DOI: 10.1039/D4QO01272K. 2. Zhang, Zhiqin.; Wang, Jianwei; Yu, Chengfeng (2023届本科生); Tan, Jiajing; Du, Hongguang;* Chen, Ning.* Visible-Light-Induced Acylative Pyridylation of Styrenes. Org. Lett. 2024, 26, 4727 – 4732. 3. Fu, Yuqing; Leng, Yijia; Bai, Haotong; Xu, Jiaxi; Chen, Ning. Regioselective oxidative cleavage of conjugated dienes to access α,β-unsaturated nitriles. Org. Chem. Front. 2024, 11, 3263–3269. 4. Zhang, Kun; Liu, Shiqi; Wang, Leyi.; Liu, Xiangrui; Xu, Jiaxi; Chen, Ning. Annuloselectivity of Dibenzoxazepines and Arynes in the Presence of CO2: [2+2] vs [2+2+2] Annulation. ChemistrySelect2024, 9,e202304458. 5. Chen, Yixin; (2021级本科生) Cheng, Shi, Su, Chongjie, Chen, Ning*, Xu, Jiaxi.* Theoretical mechanistic insights into the electrophilic addition of hydrogen halides to alkynes. Org. Biomol. Chem. 2023, 21, 7194-7208. 6. Wang, Jing; Wang, Tingting; Du, Hongguang; Chen, Ning;* Xu, Jiaxi; Yang, Zhanhui.* Accessing para-Alkylphenols via Iridium-Catalyzed Site-Specific Deoxygenation of Alcohols. J. Org. Chem. 2023, 88, 12572–12584. 7. Liu, Shiqi; Zhang, Kun; Meng, Yutong; Xu, Jiaxi;* Chen, Ning*Aryne and CO2-based formal [2+2 +2] annulation to access tetrahydroisoquinoline-fused benzoxazinones. Org. Biomol. Chem. 2023, 21, 6892–6897. 8. Huo, Haonan; Cheng, Xingdi; Xu, Jiaxi; Lin, Jiaqi;* Chen, Ning; * Lu, Xueguang.* A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles. J. Mater. Chem. B. 2023, 11, 4171-4180. (IP: 7.57) 10. Wang, Chenxing; Xu, Jiaxi; Chen, Ning.* N1-Methylthiomethylation of (8-Aza)6-Chloropurine with DMSO through the Pummerer Rearrangement. ChemistrySelect2023, 8, e202203972. 11. Hu, Junbin; Wang, Chenxing; Yu, Mingwu; Zhang, Shaojuan; Chen, Ning;* Du, Hongguang.* Palladium-Catalyzed N3-Directed C−H Halogenation of N9-Arylpurines and Azapurines. Eur. J. Org. Chem. 2022(8), e202101266. 12. Qi, Peng; Sun, Fang; Chen, Ning*; Du, H. G*. Direct Bis-Alkyl Thiolation for Indoles with Sulfinothioates under Pummerer-Type Conditions. J. Org. Chem. 2022, 87, 1133–1143. 13. Wu, Qiuyue; Chen, Ning; Xu, Jiaxi.* Chemoselectivity in the Transannulation of 1,2,3-Thiadiazoles and Alk-2-enenitriles: Specific Synthesis of 3-(Alk-1-enyl)isothiazoles. ChemistrySelect, 2022, 7(4), 202103943. 14. Wang, Tingting; Chen, Yang; Chen, Ning, Xu, Jiaxi, Yang, Zhanhui.* Iridium-catalyzed highly stereoselective deoxygenation of tertiary cycloalkanols: stereoelectronic insights and synthetic applications. Org. Biomol. Chem., 2021,19, 9004~9011. 15. Qi, Peng; Sun, Fang; Chen, Ning; Du, HongGuang.* Cross-Dehydrogenative Coupling of Azoarenes with Dialkyl Disulfides. J. Org. Chem. 2020, 85, 8588~8596. 16. Liu, Jun; Yang, Zhanhui; Zhang, Minfang; Wu, Hongfei; Chen, Ning,* Xu, Jiaxi*. Cobalt-Catalyzed Cyclosimerization of N,N-Diallylanilines. Synthesis2019, 3320~3326. 17. Li, Xiang; Chen, Ning;* Xu, Jiaxi*. Microwave-assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino alcohols. Synthesis2019, 51, 3336~3344. 18. Tian, Miao; Chen, Ning;* Xu, Fangming; Li, Xiuxiu; Li, Shunlai; Du, Hongguang.* Expedient synthesis of 2-alkylthio-N6-aryladenosines from guanosine. J. Sulfur Chem. 2018, 39, 8~22. π 19. Zhong, Xin; Chen, Ning;* Xu, Jiaxi.*A concise synthesis of cyclobrassinin and its analogues via a thiyl radical aromatic substitution. New J. Chem.2018, 42 13549~13557. 20. Fu, Zhicheng; Yuan, Wenhao; Chen, Ning; Yang, Zhanhui; * Xu, Jiaxi. * Na2S2O8-mediated efficient synthesis of isothiocyanates from primary amines in water. Green Chem., 2018, 20, 4484~4491. 21. 阙楚强, 陈宁, *许家喜. *氨基甲酸酯在C‒H键活化中的应用. 化学进展, 2018, 30, 139~155. 22. Miao Tian, Mingwu Yu, Tingting Shi, Junbin Hu, Shunlai Li, Jiaxi Xu. Ning Chen,* Hongguang Du.* Silver-Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids. Eur. J. Org. Chem. 2017, 3415–3420. 23. Chen, N.; + Dai, X.-J.; + Wang, H.; + Li, C.-J.* Umpolung Addition of Aldehydes to Aryl Imines. Angew. Chem., Int. Ed. 2017, 56, 6260–6263. 24. Liu, W.; Chen, N.; Yang, X.; Li, L.; Li, C.-J., Dehydrative condensation of carbonyls with non-acidic methylenes enabled by light: synthesis of benzofurans. Chem. Commun. 2016,52, 13120–13123. 25. Gao, Simiao; Zhang, Yu; Dong, Jun; Chen, Ning;* Xu, Jiaxi.* Synthesis of Functionalized 5-Sub- stituted Thiazolidine-2-thiones via Adscititious Xanthates-Promoted Radical Cyclization of Allyl(alkyl/aryl)dithiocarbamates. Org. Biomol. Chem.; 2016, 14, 1002-1012. 26. Wang, Jiandong; Li, Pingfan; Yang, Zhanhui; Chen, Ning; Xu, Jiaxi. Insights into the diastereoselective control in the sulfa-Michael addition of thiols to nitroalkenes: Stereoelectronic effect in the cyclic chelated transition state. Tetrahedron; 2016, 72, 370–378. 27. Chen, Ning; Du, Hongguang; Liu, Weidong; Wang, Shanshan; Li, Xinyao; Xu, Jiaxi. Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-thione Derivatives. Phosphorus, Sulfur, and Silicon.2015. 109, 1–11. 28. Du, Hongguang; He, Qiwen; Chen, Ning; Xu, Jiaxi; Chen, Fei; Liu, Guocheng. Proton NMR investigations on 6-alkylamino-2-alkylthioadenosine derivatives. Magnetic Resonance in Chemistry.2015, 53, 218–222. 29. Chen, Ning; Zhong, Xin; Li, Pingfan; Xu, Jiaxi. A Mild Radical Method for the Dimerization of Dithiocarbamates. European Journal of Organic Chemistry.2015, 802–809. 30. Yang, Zhanhui; Chen, Ning; Xu, Jiaxi. Substituent-Controlled Annuloselectivity and Stereoselectivity in the Sulfa-Staudinger Cycloadditions. J. Org. Chem.; 2015, 80 (7), pp 3611–3620. 31. Wang, Jiandong; Chen, Ning;* Xu, Jiaxi.* Diastereoselectivity in the triethylamine-catalyzed sulfa-Michael addition of thiols to nitroalkenes: Kinetic and thermodynamic control. Tetrahedron, 2015, 23, 4007-4014. 32. Chen, Zhengwang; Zeng Huiying; Girard, Simon A.; Wang, Feng; Chen, Ning; Li, Chao-Jun.* Formal Direct Cross-Coupling of Phenols with Amines. Angew. Chem. Int. Ed.; 2015, 54, 14487-14491. 33. Chen, Ning; Hou, Shili; Xu, Jiaxi. Application of benzidine rearrangement in organic synthesis. China Science Paper. 2013, 8(9), 851–855. 34. Kakaei, Saeed; Chen, Ning; Xu, Jiaxi. Expeditious synthesis of 1-substituted taurines with diverse functionalized side-chains. Tetrahedron 2013, 69, 302-309. 35. Meng, Fanhua; Chen, Ning; Xu, Jiaxi. An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides. Sci China Chemistry Series B. 2012, 55(12), 2548-2553. (Feature Article) 36. Chen, Ning; Xu, Jiaxi. Facile synthesis of various substituted taurines, especially syn- and anti-1,2-disubstituted taurines, from nitroolefins. Tetrahedon, 2012, 68(11), 2513-2522. 37. Liu, Guocheng; Xu, Jiaxi, Yu, Mingwu, Chen, Ning. Ding, Zhongren, Du, Hongguang. New approach to synthesize symmetrical and unsymmetrical 6-(N-alkyl(aryl)amino)- and 6-(N,N-dialkyl(aryl)amino)-2,4-bis(alkyl(aryl)thio- pyrimidines as antiplateletagents.) Phosphorus, Sulfur, and Silicon and the Rel. Elem. 2012,187(5), 650-659. 38. Liu, Guocheng; Xu, Jiaxi; Chen, Ning; Zhang, Si; Ding, Zhongren; Du, Hongguang Synthesis of N(6)-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents. European Journal of Medicinal Chemistry2012, 53, 114-123. 39. Liu, Guocheng; Xu, Jiaxi; Park, Ki Chul; Chen, Ning; Zhang, Si; Ding, Zhongren; Wang, Feng; Du, Hongguang. Novel synthesis approach and antiplatelet activity evaluation of 6-alkylamino-2,4-dialkyl(aryl)thiopyrimidines. Tetrahedron, 2011, 67(29), 5156-5161. 40. Chen, Ning; Huang, Zhongyan; Zhou, Chan; Xu, Jiaxi. Thorpe-Ingold effect in the reaction of vicinal amino primary alcohol hydrogen sulfates and carbon disulfide. Tetrahedron. 2011, 67(41), 7971-7976. 41. Wang, Zhixin;Chen, Ning; Xu, Jiaxi. Selectivities in the reaction of vicinal diimines and acyl chlorides. Tetrahedron, 2011, 67, 9690-9699. DOI:10.1016/j.tet.2011.10.044. 42. Xiaobing Deng, Ning Chen, Zhixin Wang, Xinyao Li, Hongyan Hu, Jiaxi Xu. A Convenient Synthesis of Thiazolidin-2-ones from Thiazolidine-2-thiones: Antibiotic Activity and Revisiting the Mechanism. Phosphorus, Sulfur, and Silicon and the Rel. Elem.2011, 186, 1563–1571. 43. Xinyao Li, Ning Chen, Jiaxi Xu. An Improved and Mild Wenker Synthesis of Aziridines. Synthesis, 2010, (20), 3423–3428. 44. Chen, Ning; Zhu, Min; Zhang, Wei; Du, Da-Ming; Xu, Jiaxi Xu. Synthesis of gem-disubstituted taurines by the regioselective ring-opening of 2,2-disubstituted aziridines with sodium bisulfite and sulfite. Amino Acids2009, 37, 309-313. 45. Chen, Ning; Jia, Weiyi; Xu, Jiaxi. A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines. Eur. J. Org. Chem.2009, 5841-5846. 46. Chen, Ning; Xu, Jiaxi. HCOOH, an Inexpensive, Convenient, and Practical 13C NMR Solvent for Strong Polar Amino Acids and their Derivatives. Lett. Org. Chem.2009, 6(4), 349-353. 47. Wei Zhang, Boyuan Wang, Ning Chen, Da-Ming Du, Jiaxi Xu.Expeditious and Practical Synthesis of Various Substituted Taurines from Amino Alcohols. Synthesis, 2008, 2, 197-200. 48. Zhu, Min; Hu, Libo; Chen, Ning; Du, Da-Ming; Xu, Jiaxi. Synthesis of NH-aziridines from vicinal amino alcohols via the Wenker reaction: Scope and limitation. Lett. Org. Chem., 2008, 5(3), 212-217. AwardsPatentHonor RewardAdmissions Information |