IntroductionZhang Guimin is a professor and doctoral supervisor at Beijing University of Chemical Technology. She is mainly engaged in the research and development of biocatalysis and biosensor, and is good at molecular modification of proteins and enzymes and efficient expression technology of Pichia pastoris. She has presided over 11 national projects, including 6 NSFC projects and 3 National Key R&D projects of China. In the past 5 years, she has published 35 SCI papers as the corresponding author in journals such as Nucleic Acids Research, ACS Sustainable Chemistry & Engineering, Biosensors and Bioelectronics, and Food Chemistry etc., including 30 papers in the CAS Category II journals. She has authorized 25 invention patents, achieved 8 results transfer, and won 5 provincial and ministerial science and technology awards as the first or second class finisher. She is currently a member and Deputy Secretary-General of the Expert Committee of the Industrial Enzyme Industry Technology Innovation Strategic Alliance of the MOST, a member of the Enzyme Engineering Professional Committee of the CSM, and an editorial board member of the Acta Microbiologica Sinica. She was formerly the chairman of the Enzyme Engineering Professional Committee of Hubei Province and Wuhan City. She has won the Henry Fok Young Teacher Award, Hubei Province Outstanding Youth Fund, Hubei Province Young and Middle-aged Distinguished Contribution Expert, etc. EducationWork ExperienceSocial PositionSocial ActivitiesResearchTeachingMicrobiology PostgraduatesFundingVertical ProjectHorizontal ProjectPublications1. Yingying Liang#, Hailin Liua#, Lin Wang#, Jing Zhao, Shunyi Li, Li Yi, Sijing Jiang*, Zhenghui Lu *, Guimin Zhang*. A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds. Sensors and Actuators B: Chemical, 2024 2. Nisha He#, Qin Wei#, Yiwen Li#, Shantong Hu, Yufan Xian, Mo Yang, Pan Wu, Zhenghui Lu*, Guimin Zhang*. A sensitive, portable, and smartphone-based whole-cell biosensor device for salicylic acid monitoring. Biosensors and Bioelectronics, 2024 4. La Xiang, Xinlin Hu, Chao Du, Lian Wu, Zhenghui Lu, Jiahai Zhou*, Guimin Zhang*. N-terminal domain truncation yielded a unique dimer of polysaccharide hydrolase with enhanced enzymatic activity, stability and calcium ion independence. International Journal of Biological Macromolecules. 2024 5. Meng Mei, Xian Fan, Yu Zhou, Faying Zhang, Guimin Zhang*, and Li Yi*. A Combinatorial Strategy for HRV 3C Protease Engineering to Achieve the N-terminal Free Cleavage. International Journal of Biological Macromolecules. 2024 7. Meixing Wang#, Faying Zhang#, La Xiang#, Mengsha Li, Zhenghui Lu, Pan Wu, Xiang Sheng, Jiahai Zhou, and Guimin Zhang*. Enhancing the Activity of Zearalenone Lactone Hydrolase towards the More Toxic α-Zearalanol via a Single-Point Mutation.Applied and Environmental Microbiology, 2024 8. Meixing Wang, Yufan Xian, Zhenghui Lu, Pan Wu, Guimin Zhang*. Engineering polysaccharide hydrolases in the product-releasing cleft to alter their product profiles, International Journal of Biological Macromolecules, 2024 9. Chao Du, Yuling Zhou, Lin Liu, Meixing Wang, Sijing Jiang, Yifei Zhang*, Guimin Zhang. * Bacterial surface-assembled chitinosome for dismantling chitin into N-acetyl glucosamine, ACS Sustainable Chemistry & Engineering, 2023 10. Faying Zhang, Xian Fan, Ke Xu, Shihui Wang, Shuobo Shi, Li Yi*, Guimin Zhang*. Development of Bacterial FhuD-lysozyme-SsrA mediated autolytic (FLSA) system for effective release of intracellular products, ACS Synthetic Biology, 2023 11. Zhenghui Lu, Shihui Yang, Xin Yuan, Yunyun Shi, Li Ouyang, Sijing Jiang, Li Yi and Guimin Zhang*. CRISPR-assisted multi-dimensional regulation for fine-tuning gene expression in Bacillus subtilis. Nucleic Acids Research, 2019, 47(7): e401, doi: 10.1093/nar/gkz072 13. Zhenghui Lu, Xinzhi Li, Rui Zhang, Li Yi, Yanhe Ma, Guimin Zhang*. Tunnel engineering to accelerate product release for better biomass-degrading abilities in lignocellulolytic enzymes. Biotechnology for Biofuels, 2019，12:275 14. Xian Fan, Xinzhi Li, Yu Zhou, Meng Mei, Pi Liu, Jing Zhao, Wenfang Peng, Zhengbing Jiang, Shihui Yang, Brent L. Iverson, Guimin Zhang*, and Li Yi*. Quantitative analysis of the substrate specificity of human rhinovirus 3C protease and exploration of its substrate recognition mechanisms, ACS Chemical Biology, 2019 15. Wang Shengchen, Faying Zhang, Meng Mei, Ting Wang, Yueli Yun, Shihui Yang, Guimin Zhang*, and Li Yi*. A split protease-E. coli ClpXP system quantifies protein–protein interactions in Escherichia coli cells. Communications Biology, 2021 16. Chao Du, Shun Jiang, Sijing Jiang, Yuling Zhou*, Guimin Zhang*. A Bacillus pumilus originated β-N-acetylglucosaminidase for chitin combinatory hydrolysis and exploration of its thermostable mechanism. International Journal of Biological Macromolecules, 2019, 132: 1282-1289 17. Meixing Wang, Lifeng Yin, Huizhen Hu, Jonathan Nimal Selvaraj, Yuling Zhou, Guimin Zhang*. Expression, functional analysis and mutation of a novel neutral zearalenone-degrading enzyme, International Journal of Biological Macromolecules, 2018,118(Pt A):1284-1292 18. Zhenghui Lu, Xinlin Hu, Panpan Shen, Qinhong Wang, Yuling Zhou, Guimin Zhang*, Yanhe Ma. A pH-stable, detergent and chelator resistant type I pullulanase from Bacillus pseudofirmus 703 with high catalytic efficiency. International Journal of Biological Macromolecules, 2018 Apr 1;109:1302-1310. 19. Shengchen Wang, Qinhong Wang, Yuling Zhou, Zhenghui Lu, Guimin Zhang*, Yanhe Ma. A new GH13 α-glucosidase from alkaliphilic Bacillus pseudofirmus 703 with both exo-α-l, 4-glucosidase and oligo-l, 6-glucosidase activities towards amylopectin. International Journal of Biological Macromolecules, 2017, 101: 973-982 AwardsPatentHonor RewardAdmissions Information |