IntroductionEducationWork ExperienceHe joined Beijing University of Chemical Technology (BUCT) through talent project in 2017, and was awarded the support of Hundred Talents Programme for young talents of BUCT in 2019. He is a member of the Chinese Chemical Society, the Chinese Society for Biomaterials, an expert of the National Natural Science Foundation of China, and a reviewer for many academic journals at home and abroad. As a project leader, he has undertaken a number of research projects, including the National Natural Science Foundation of China (NSFC) Youth, Upper-level Project, Excellent Youth Fund Project, and ZBYY Joint Fund Project of the Ministry of Education of China. He has published articles in Nature Nanotechnology, Advanced Materials, Advanced Functional Materials, ACS Nano, Journal of Controlled Release, ACS Applied Materials & He has published more than 40 scientific papers in domestic and international journals, such as Nature Nanotechnology, Advanced Materials, Functional Materials, ACS Nano, Journal of Controlled Release, ACS Applied Materials & Interfaces, Biomacromolecules, etc. He has applied for 22 national invention patents, and 11 were granted. Research Teaching
TeachingPostgraduates Funding
FundingVertical ProjectHorizontal ProjectPublications1.Yu, S.; Jiang, Y.; Li, Q.; Li, M.; Su, J.; Lai, S.; Gan, Z.; Ding, Z.*; Yu, Q.*, Nano-sensitizer with self-amplified drug release and hypoxia normalization properties potentiates efficient chemoradiotherapy of pancreatic cancer. Biomaterials 2024,310, 122634. 2.Yang, C.; Jiang, Y.; Zhang, K.; Zhu, X.; Li, J.; Yu, H.; Chen, J.; Gu, X.*; Gan, Z.; Yu, Q.*, Photodynamic Therapy Derived Personalized Whole Cell Tumor Vaccine Prevents Postsurgery Tumor Recurrence and Metastasis. Small 2024,20 (28), 2308456. 3.Li, J.; Yu, H.; Kang, Y.; Niu, K.; Wang, M.; Jiang, Y.; Jiang, N.; Ding, Z.*; Gan, Z.*; Yu, Q.*, STING Membrane Prevents Post-Surgery Tissue Adhesion and Tumor Recurrence of Colorectal Cancer. Advanced Materials 2024,36 (21), 2309655. 4.Hu, B.; Chen, J.; Gao, Z.; Chen, L.; Cao, T.; Li, H.; Yu, Q.*; Wang, C.; Gan, Z., Biodegradable MXene Quantum Dots with High Near-Infrared Photothermal Performance for Cancer Treatment. ACS Applied Bio Materials 2024,7 (7), 4339-4351. 5.Yang, C.; Guo, L.; Zhang, K.; Wang, G.; Yu, Q.*; Gan, Z.; Gu, X., Diradical-Featured Organic Small-Molecule Photothermal Material Based on 4,6-di(2-thienyl)thieno[3,4-c][1,2,5]thiadiazole for Photothermal Immunotherapy. Advanced Functional Materials 2023,33 (52), 2306360. 6.Liu, K.; Mo, Q.; Ding, Z.; Lai, S.; Ren, J.*; Yu, Q.*, Nano theranostics involved in bladder cancer treatment. Exploration of Drug Science 2023,1 (2), 81-106. 7.Gong, H.; Ding, Z.; Jiao, B.; Ren, J.*; Yu, Q.*, Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms. Advanced Sensor Research 2023,2 (9), 2300037. 8.Chen, J.-W.; Shen, Y.; Yu, Q.-S.*; Gan, Z.-H., Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy. Chinese Journal of Polymer Science 2023. 9.Zhu, X.; Li, L.; Tang, J.; Yang, C.; Yu, H.; Liu, K.; Zheng, Z.; Gu, X.*; Yu, Q.*; Xu, F.-J.; Gan, Z., Cascade-Responsive Nano-Assembly for Efficient Photothermal-Chemo Synergistic Inhibition of Tumor Metastasis by Targeting Cancer Stem Cells. Biomaterials 2022,280, 121305. 10.Zhang, P.; Ouyang, Q.; Zhai, T.; Sun, J.; Wu, J.; Qin, F.; Zhang, N.; Yue, S.; Yang, X.; Zhang, H.; Hou, Y.; Deng, L.; Wang, F.; Zhan, Q.*; Yu, Q.*; Qin, M.*; Gan, Z., An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy. Nanoscale 2022,14 (41), 15291-15304. 11.Zhang, L.; Du, X.; Li, Q.; Qian, L.; Chen, J.; Liu, C.; Yu, Q.*; Gan, Z*., A Multimodal Therapeutic Nanoplatform Overcoming Tumor Hypoxia Heterogeneity for Improved Tumor Chemoradiotherapy. Advanced Functional Materials 2022,32 (34), 2204629. 12.Tang, X.; Du, X.; Yu, Y.; Qin, M.; Qian, L.; Zhang, M.; Yang, Y.; Yu, Q.*; Gan, Z.*, Deep-Penetrating Triple-Responsive Prodrug Nanosensitizer Actuates Efficient Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma Models. Small 2022,18 (31), 2202834. 13.Qian, L.; Li, Q.; Ding, Z.; Luo, K.; Su, J.; Chen, J.; Zhu, G.*; Gan, Z.; Yu, Q.*, Prodrug Nanosensitizer Overcomes the Radiation Resistance of Hypoxic Tumor. ACS Applied Materials & Interfaces 2022,14 (51), 56454-56470. 14.Li, Y.; Jiang, Y.; Zheng, Z.; Du, N.; Guan, S.; Guo, W.; Tang, X.; Cui, J.; Zhang, L.; Liu, K.*; Yu, Q.*; Gan, Z., Co-Delivery of Precisely Prescribed Multi-Prodrug Combination by an Engineered Nanocarrier Enables Efficient Individualized Cancer Chemotherapy. Advanced Materials 2022,34 (12), 2110490. 15.Jiao, B.; Liu, K.; Gong, H.; Ding, Z.; Xu, X.; Ren, J.; Zhang, G.*; Yu, Q.*; Gan, Z.*, Bladder cancer selective chemotherapy with potent NQO1 substrate co-loaded prodrug nanoparticles. Journal of Controlled Release 2022,347, 632-648. 16.Yu, Y.; Xiang, K.; Xu, M.; Li, Y.; Cui, J.; Zhang, L.; Tang, X.; Zhu, X.; Qian, L.; Zhang, M.; Yang, Y.; Yu, Q.*; Shen, Y.; Gan, Z., Prodrug Nanomedicine Inhibits Chemotherapy-Induced Proliferative Burst by Altering the Deleterious Intercellular Communication. ACS Nano 2021,15, 781-796. 17.Shi, R.; Zhang, J.; Niu, K.; Li, W.; Jiang, N.; Li, J.; Yu, Q.; Wu, C., Electrospun Artificial Periosteum Loaded with DFO Contributes to Osteogenesis via the TGF-β1/Smad2 Pathway. Biomaterials Science 2021,9, 2090-2102. 18.Xu, X.; Liu, K.; Jiao, B.; Luo, K.; Ren, J.; Zhang, G.*; Yu, Q.*; Gan, Z.*, Mucoadhesive Nanoparticles based on ROS Activated Gambogic Acid Prodrug for Safe and Efficient Intravesical Instillation Chemotherapy of Bladder Cancer. Journal of Controlled Release 2020,324, 493-504. 19.Qin, M.; Cao, Z.; Wen, J.; Yu, Q.; Liu, C.; Wang, F.; Zhang, J.; Yang, F.; Li, Y.; Fishbein, G.; Yan, S.; Xu, B.; Hou, Y.; Ning, Z.; Nie, K.; Jiang, N.; Liu, Z.; Wu, J.; Yu, Y.; Li, H.; Zheng, H.; Li, J.; Jin, W.; Pang, S.; Wang, S.; Chen, J.; Gan, Z.; He, Z.; Lu, Y., An Antioxidant Enzyme Therapeutic for COVID-19. Advanced Materials 2020,32. 20.Luo, K.; Guo, W.; Yu, Y.; Xu, S.; Zhou, M.; Xiang, K.; Niu, K.; Zhu, X.; Zhu, G.; An, Z.; Yu, Q.*; Gan, Z.*, Reduction-Sensitive Platinum (IV)-Prodrug Nano-Sensitizer with an Ultra-High Drug Loading for Efficient Chemo-Radiotherapy of Pt-Resistant Cervical Cancer in vivo. Journal of Controlled Release 2020,326, 25-37. 21.Zhou, Q.; Shao, S.; Wang, J.; Xu, C.; Xiang, J.; Piao, Y.; Zhou, Z.; Yu, Q.; Tang, J.; Liu, X.; Gan, Z.; Mo, R.; Gu, Z.; Shen, Y., Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy. Nature Nanotechnology 2019,14, 799-809. 22.Zhang, Y.; Fang, Q.; Niu, K.; Gan, Z.; Yu, Q.*; Gu, T.*, Time-Dependently Slow-Released Multiple-Drug Eluting External Sheath for Efficient Long-Term Inhibition of Saphenous Vein Graft Failure. Journal of Controlled Release 2019,293, 172-182. 23.Zhang, X.; He, F.; Xiang, K.; Zhang, J.; Xu, M.; Long, P.; Su, H.; Gan, Z.*; Yu, Q.*, CD44-Targeted Facile Enzymatic Activatable Chitosan Nanoparticles for Efficient Antitumor Therapy and Reversal of Multidrug Resistance. Biomacromolecules 2018,19, 883-895. 24.Zhang, J.; Tang, H.; Shen, Y.; Yu, Q.*; Gan, Z.*, Shell-Sheddable Poly(N-2-Hydroxypropyl methacrylamide) Polymeric Micelles for Dual-Sensitive Release of Doxorubicin. Macromolecular Rapid Communications 2018,39, 1800139. 25.Tang, H.; Zhang, J.; Tang, J.; Shen, Y.; Guo, W.; Zhou, M.; Wang, R.; Jiang, N.; Gan, Z.*; Yu, Q.*, Tumor Specific and Renal Excretable Star-like Triblock Polymer-Doxorubicin Conjugates for Safe and Efficient Anticancer Therapy. Biomacromolecules 2018,19, 2849-2862. 26.Yan, X.; Yu, Q.*; Guo, L.; Guo, W.; Guan, S.; Tang, H.; Lin, S.; Gan, Z.*, Positively Charged Combinatory Drug Delivery Systems against Multi-Drug-Resistant Breast Cancer: Beyond the Drug Combination. ACS Applied Materials & Interfaces 2017,9, 6804-6815. 27.Shen, T.; Xu, X.; Guo, L.; Tang, H.; Diao, T.; Gan, Z.; Zhang, G.*; Yu, Q.*, Efficient Tumor Accumulation, Penetration and Tumor Growth Inhibition Achieved by Polymer Therapeutics: The Effect of Polymer Architectures. Biomacromolecules 2017,18, 217-230. 28.Shen, T.; Guan, S.; Gan, Z.; Zhang, G.*; Yu, Q.*, Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation. Biomacromolecules 2016,17, 1801-1810. 29.Du, N.; Guo, W.; Yu, Q.*; Guan, S.; Guo, L.; Shen, T.; Tang, H.; Gan, Z.*, Poly(D,L-Lactic Acid)-block-poly(N-(2-Hydroxypropyl) methacrylamide) Nanoparticles for Overcoming Accelerated Blood Clearance and Achieving Efficient Anti-Tumor Therapy. Polymer Chemistry 2016,7, 5719-5729. 30.Yu, Q.; Zhang, J.; Zhang, G.; Gan, Z., Synthesis and Functions of Well-Defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer. Macromolecular Bioscience 2015,15, 509-520. 31.Yu, Q.; Wei, Z.; Shi, J.; Guan, S.; Du, N.; Shen, T.; Tang, H.; Jia, B.; Wang, F.; Gan, Z., Polymer-Doxorubicin Conjugate Micelles Based on Poly(Ethylene Glycol) and Poly(N-(2-Hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules 2015,16, 2645-2655. 32.Yu, Q.; Dong, C.; Zhang, J.; Shi, J.; Jia, B.; Wang, F.; Gan, Z., Synthesis of Poly(Ethylene Glycol)-b-Poly(N-(2-Hydroxypropyl) methacrylamide) Block Copolymers with Well-Defined Structures and Their Influence on in vivo Circulation and Biodistribution. Polymer Chemistry 2014,5, 5617-5627. Awards
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