Hou Yi头像

Hou Yi

Associate professor

Research direction: Molecular Imaging & Nanomedicine

Education:

10 Access

  • Email: houyi@iccas.ac.cn
  • Office :
  • Introduction
  • Research
  • Teaching
  • Funding
  • Publications
  • Awards
  • Honor Reward
  • Admission

Introduction

Education

Work Experience

Social Position

Social Activities

Research

1.Constructinghypersensitive molecular imaging nanoprobes for tumor diagnosis;

2.Establishing the“multitarget-triggered logic” nanoprobes fordisclosing the correlation between tumor-associatedmicroenvironments and tumor behaviors;

3.Exploiting thenanoparticle-protein corona to improve tumor targeting ofnanomedicine.

Teaching

Molecular Imaging



Postgraduates

Funding

Vertical Project

Horizontal Project

Publications

1.             Wenyue Li, Junwei Cheng, Chuang Liu, Ni Zhang, Hua Lin, Fangfei He, Zhihua Gan, Peisen Zhang*, Meng Qin*, and Yi Hou* Shine and Darkle the Blood Vessels: Multi-parameter Hypersensitive MR Angiography for Diagnosis of Panvascular Diseases Sci. Adv. 2024, 10, eadq4082.

2.             Wenyue Li, Junwei Cheng, Xinyi Zhang, Yuqing Wang, Peisen Zhang*, Zhihua Gan, and Yi Hou* High-Resolution Magnetic Resonance Angiography of Tumor Vasculatures with an Interlocking Contrast Agent ACS Nano 2024, 18, 25647-25656.

3.             Peisen Zhang#, Junwei Cheng#, Chuang Liu#, Wenyue Li, Yuqing Wang, Ni Zhang, Jin Wu, Xinyu Zhang, Chaoyong Liu, and Yi Hou* Hypersensitive MR Angiography for Diagnosis of Ischemic Stroke and Reperfusion Subarachnoid Hemorrhage Anal. Chem. 2024, 96, 11742-11750.

4.             Wenyue Li#, Ruru Zhang#, Xinyi Zhang, Shuai Wu, Tiancong Ma, Yi Hou*, Jianfeng Zeng*, and Mingyuan Gao* Precise diagnosis of cardiac‐cerebral vascular diseases with magnetic resonance imaging‐based nanoprobesiRadiology 2024, 2, 26-284.

5.             Fangfei He#, Xiaohan Zhou#, Junwei Cheng#, Peisen Zhang, Jun Zhao, Yan Liang, Yi Hou*, Wentao Liu*, and Dong Han* MRI-based interstitial fluid velocity analysis for drug delivery efficiency evaluation in tumor Anal. Chem. 2024, 96, 204-211.

6.             Peisen Zhang#, Junwei Cheng#, Yijie Lu#, Ni Zhang, Xiaoai Wu, Hua Lin, Wei Li*, Jian Wang, Mitchell A. Winnik, Zhihua Gan*, and Yi Hou* Hypersensitive MR Angiography based on Interlocking Stratagem for Diagnosis of Cardiac-cerebral Vascular Diseases Nat. Commun. 2023, 14, 6149.

7.             Peisen Zhang#, Yuanyuan Qiao#, Lichong Zhu, Meng Qin, Qilong Li, Chuang Liu, Yuping Xu, Xin Zhang, Zhihua Gan,* and Yi Hou* Nanoprobe Based on Biominerals in Protein Corona for Dual-Modality MR Imaging and Therapy of Tumors ACS Nano 2023, 17, 184-196.

8.             Peisen Zhang#, Yicheng Feng#, Lichong Zhu, Kunyao Xu, Qiuhong Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang Shi, Gang Chen, Zhe Shi, Meng Qin*, Yi Hou*, Mingyuan Gao* Predicting Thrombolytic Haemorrhage Risk of Acute Ischemic Stroke through Angiogenesis/Inflammation Dual-targeted MR Imaging Nano Today 2023, 48, 101707.

9.             Peisen Zhang#, Wenyue Li#, Chuang Liu, Lichong Zhu, Junwei Cheng, Runxin Pang, Yue Lan*, Meng Qin*, and Yi Hou* Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low-immunogenic MRI nanoprobe Mater. Design 2023, 233, 112211.

10.         Wenyue Li, Peisen Zhang*, Chuang Liu, Yuping Xu, Zhihua Gan, Lei Kang* and Yi Hou* Oncogene-Targeting Nanoprobes for Early Imaging Detection of Tumor J. Nanobiotechnol. 2023, 21, 197.

11.         Sitong Wu, Kevin Fan, Qi Yang, Zhao Chen, Yi Hou*, Yinghua Zou*, Weibo Cai* and Lei Kang* Smart nanoparticles and microbeads for interventional embolization therapy of liver cancer: state of the art J. Nanobiotechnol. 2023, 21, 42.

12.         Lichong Zhu, Wenyue Li, Chuang Liu, Saisai Yue, Yuanyuan Qiao, Yingying Cui, Junwei Cheng, Ming Zhang, Peisen Zhang*, Beibei Zhang*, and Yi Hou* Glutathione-sensitive Mesoporous Nanoparticles Loaded with Cinnamaldehyde for Chemodynamic and Immunological Therapy of Cancer J. Mater. Chem. B2023, 11, 8717-8731.

13.         Xiaohan Zhou#, Junwei Cheng#, Fangfei He, Zhuo Ao, Peisen Zhang, Jing Wang, Qing Li, Weinan Tang, Yiyan Zhou, Yan Liang, Yi Hou*, Wentao Liu* and Dong Han* A Robust MRI contrast agent for specific display on the interstitial stream Nanoscale Adv. 2023, 5, 3913.

14.         Peisen Zhang, Wenyue Li, Chuang Liu, Feng Qin, Yijie Lu*, Meng Qin*, and Yi Hou* Molecular Imaging of Tumor-associated Pathological Biomarkers with Smart Nanoprobe: from “Seeing” to “Measuring” Exploration. 2023, 3, 20230070.

15.         Yuping Xu#, Peisen Zhang#, Shuming Jin#, Chuang Liu, Lin Yang, Zhuo Ao, Meng Qin, Kaili Nie, Yi Hou*, and Mingyuan Gao* Tracking How Biodegraded Microplastics Enter the Ecosystem with CuInS2@ZnS QDs J. Phys. Chem. C 2022, 126, 20605-20612.

16.         Saisai Yue, Peisen Zhang*, Meng Qin, Lichong Zhu, Yuanyuan Qiao, Qilong Li, Yijie Lu, Hao Wu, Ni Jiang, Chaoyong Liu, Mitchell A. Winnik*, and Yi Hou* An Enzyme-like Activity Nanoprobe Based on Fe(III)-Rutin Hydrate Biomineral for MR Imaging and Therapy of Triple Negative Breast Cancer Adv. Funct. Mater. 2022, 32, 2202848.

17.         Yan Fang, Ruichen Yang, Yi Hou*, Yabin Wang, Ning Yang, Mengqi Xu, Sulei Li, Shan Gao, Min Jiang, Jingyang Fan, Yazhuo Hu, Zhenzhen Xu, Lei Gao*, and Feng Cao Dual-modality Imaging of Angiogenesis in Unstable Atherosclerotic Plaques with VEGFR2-Targeted Upconversion Nanoprobes in vivo Mol. Imaging Biol. 2022, 24, 721-731.

18.         Saisai Yue#, Xin Zhang#, Yuping Xu#, Lichong Zhu, Junwei Cheng, Yuanyuan Qiao, Suyang Dai, Jialin Zhu, Ni Jiang, Hao Wu*, Peisen Zhang*, and Yi Hou* The Influences of Surface Charge on the Tumor Targeting of Fe3O4 Nanoparticles for MRI J. Mater. Chem. B2022, 10, 646-655.

19.         Peisen Zhang#, Jianfeng Zeng#, Yingying Li, Chen Yang, Junli Meng, Yi Hou*, and Mingyuan Gao* Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe Angew. Chem. Int. Ed.2021, 60, 8130-8138.

20.         Fulei Zhang#, Yi Hou#, Minhui Zhu#, Bo Deng#, Mengxin Zhao, Xiandi Zhu, Yun Sun, Di Chen, Cheng Jiang, Liming Wang, Chunying Chen, Huaiwen Chen, Han Chen*, Hongliang Zheng*, and Wei Li* Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods Adv. Sci.2021, 8, 2102666.

21.         Yan Yang#, Saisai Yue#, Yuanyuan Qiao#, Peisen Zhang*, Ni Jiang, Zhenbo Ning, Chunyan Liu, and Yi Hou* Activable Multi-modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors Front. Chem.2021, 8, 572471.

22.         Yi Hou*, Xiaoling Wei*, Yunfeng Yan*, and Jing Hao* Editorial: Target-Triggered Nanoparticles for Tumor Diagnosis and Therapy  Front. Chem.2021, 9, 657782.

23.         Peisen Zhang, Zihua Wang, Yiyang Wang, Yuqing Wang, Chunyan Liu, Kai Cao, Yijie Lu, Leila Behboodpour, Yi Hou*, and Mingyuan Gao MRI Contrast Agent Based on Zwitterionic Metal-chelating Polymer for Hepatorenal Angiography and Tumor ImagingJ. Mater. Chem. B2020, 8, 6956-6963.

24.         Hanyi Fang#, Mengting Li#, Qingyao Liu#, Yongkang Gai, Lujie Yuan, Sheng Wang, Xiao Zhang, Min Ye, Yongxue Zhang, Mingyuan Gao, Yi Hou*, and Xiaoli Lan* Ultra-sensitive Nanoprobe Modifed with Tumor Cell Membrane for UCL/MRI/PET Multimodality Precise Imaging of Triple-Negative Breast CancerNano-Micro Lett.2020, 12, 62.

25.         Haijie Han#, Yi Hou#, Xiaohui Chen‡, Peisen Zhang, Muxing Kang, Qiao Jin*, Jian Ji, and Mingyuan Gao* Metformin-induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy J. Am. Chem. Soc.2020, 142, 4944.

26.         Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu, Tiancong Ma, and Mingyuan Gao* Coordinatively Unsaturated Fe3+ Based Activable Probes for Enhanced MRI and Therapy of Tumors Angew. Chem. Int. Ed.2019, 58, 11088.

27.         Xiaodan Sun#, Peisen Zhang#, Yi Hou*, Yingying Li, Xiaodan Huang, Zihua Wang, Lihong Jing*, and Mingyuan Gao* Upconversion Luminescence Mediated Photodynamic Therapy through Hydrophilically Engineered Porphyrin Chem. Eng. Process.2019, 142, 107551.

28.         Peisen Zhang, Junli Meng, Yingying Li, Zihua Wang*, and Yi Hou* pH-Sensitive Ratiometric Fluorescent Probe for Evaluation of Tumor Treatments  Materials2019, 12, 1632.

29.         Tiancong Ma#, Peisen Zhang#, Yi Hou*, Haoran Ning, Zihua Wang, Jiayi Huang, and Mingyuan Gao ‘Smart’ Nanoprobes for Visualization of Tumor MicroenvironmentAdv. Health. Mater. 2018, 7, 1800391.

30.         Tiancong Ma#, Yi Hou#,Jianfeng Zeng‡, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao* Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Proteases and pH in vivoJ. Am. Chem. Soc. 2018, 140, 211-218.

31.         Ting Wang#, Yi Hou#, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou*, and Mingyuan Gao* Timely Visualization of the Collaterals Formed during Acute Ischemic Stroke with Fe3O4 Nanoparticle-based MR Imaging ProbeSmall 2018, 14, 1800573.

32.         Jiayi Huang, Yi Hou*, Tiancong Ma, Peisen Zhang, Yingying Li, Chunyan Liu, Boyuan Zhang, Shanshan Qiu, Jianfeng Zeng, and Mingyuan Gao* A Novel Histochemical Staining Approach for Rare-Earth Based NanoprobesAdv. Therap. 2018, 1, 1800005.

33.         Zhenyu Gao#, Yi Hou#, Jianfeng Zeng, Lei Chen, Chunyan Liu, Wensheng Yang*, and Mingyuan Gao* Tumor Microenvironment-Triggered Aggregation of Anti-Phagocytosis 99mTc-Labelled Fe3O4 Nanoprobes for Enhanced Tumor Imaging in Vivo Adv. Mater. 2017, 29, 1701095.

34.         Yi Hou*, Jin Zhou, Zhenyu Gao, Xiaoyu Sun, Chunyan Liu, Dihua Shangguan, Wensheng Yang, and Mingyuan Gao A Protease-Activated Ratiometric Fluorescent Probe for pH-Mapping of Malignant Tumor Adv. Sci. Technol. 2017, 102, 51-56.

35.        Tapas K.Mandal#, Yi Hou#,Zhenyu Gao, Haoran Ning, Wensheng Yang, and Mingyuan Gao* Graphene Oxide-based Sensor for Ultrasensitive Visual Detection of Fluoride Adv. Sci. 2016, 3, 1600217.

36.        Yi Hou,Jin Zhou, Zhenyu Gao, Xiaoyu Sun, Chunyan Liu, Dihua Shangguan, Wensheng Yang, and Mingyuan Gao* Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors ACS Nano 2015, 9, 3199-3205.

37.        Xiaoyu Sun, Bingru Wang, Ivan M. Kempson, Chunyan Liu, Yi Hou*, Miangyuan Gao* Restructuring and Remodeling of NaREF4 Nanocrystals by Electron Irradiation Small 2014, 10, 4711-4717.

38.        Yi Hou, Ruirui Qiao, Fang Fang, Xuxia Wang, Chengyan Dong, Kan Liu, Chunyan Liu, Zhaofei Liu, Hao Lei*, Fan Wang, Mingyuan Gao* NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts In Vivo ACS Nano 2013, 7, 330-338.

39.        Chunyan Liu, Zhenyu Gao, Jianfeng Zeng, Yi Hou*, Fang Fang, Yilin Li, RuiruiQiao, Lin Shen, Hao Lei, Wensheng Yang, Mingyuan Gao* Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-based Dual-modal Molecular Probes for in vivo Tumor Imaging ACS Nano 2013, 7, 7227-7240.

40.        Yi Hou, Ying Wu, Guangming Liu, Guangzhao Zhang* Reentrant Behavior of Grafted Poly(sodium styrenesulfonate) Chains Investigated with a Quartz Crystal MicrobalancePhys. Chem. Chem. Phys. 2011, 13, 2880-2886.

41.        Yi Hou, Changqian Yu, Guangming Liu, To Ngai, Guangzhao Zhang* Effects of Anions on the Aggregation Charged MicrogelsJ. Phys. Chem. B 2010, 114, 3799-3803.

42.        Yi Hou, Jing Ye, Xiaoling Wei, Guangzhao Zhang* Effects of Cations on the Sorting of Oppositely Charged MicrogelsJ. Phys. Chem. B 2009, 113, 7457-7461.

43.        Yi Hou, Jing Ye, Zhou Gui, Guangzhao Zhang* Temperature-Modulated Photoluminescence of Quantum DotsLangmuir 2008, 24, 9682-9685.

44.        Yi Hou, Jing Chen, Peijian Sun, ZhihuaGan*, Guangzhao Zhang* In situ Investigations on Enzymatic Degradation of Poly(ε-caprolactone) Polymer 2007, 48, 6348-6353.


Awards

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Honor Reward

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