Fengyue头像

Fengyue

Professor

Research direction: Interactions between microbes and the host immune system

Education:

  • Department: College of Life Sciences and Technology
  • ORCID:
  • DBLP:

10 Access

  • Email: fengyue@mail.buct.edu.cn
  • Office :
  • Introduction
  • Research
  • Teaching
  • Funding
  • Publications
  • Awards
  • Honor Reward
  • Admission

Introduction

Yue Feng is professor and doctoral supervisor of Beijing University of Chemical Technology. He has been engaged in biochemistry and structural biology research for many years, and his current research direction mainly focuses on the molecular mechanism of interaction between bacteriophages and bacterial immune system. A total of 50 SCI papers have been published, including 25 corresponding author papers. They were published in Nature、Cell、Mol. Cell (X 3)、Nat. Chem. Biol. (X 2)、Nat. Plants、Nat. Commun. (X 2)、PNAS、Nucleic Acids Res.、J. Biol. Chem. (X 3), such as the international famous journals.


Education

Work Experience

Social Position

Social Activities

Research

Molecular mechanisms of interactions between microbes and the host immune system

Teaching

Yue Feng undertaked the teaching of several courses including “Advanced Biochemistry” for graduate students, and “Biochemistry”, “Cell Biology and Cell Engineering” for undergraduate students.


Postgraduates

Funding

Vertical Project

Horizontal Project

Publications

1.       Zhang L, Wang H, Zeng J, Cao X, Gao Z, Liu Z, Li F, Wang J, Zhang Y, Yang M, Feng Y*. Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system, 2024, Nature Chemical Biology, doi: 10.1038/s41589-024-01659-5.

2.       Cao Xueli, Xiao Y, Huiting E, Cao Xujun, Li D, Ren J, Fedorova I, Wang H, Guan L, Wang Y, Li L, Bondy-Denomy J*, Feng Y*. Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol Cell. 2023. 84(2): 375-385.

3.       Dong Y, MuY, XieY, ZhangY, HanY, Zhou Y, WangW, LiuZ, WuM, Wang H, PanM, XuN, XuC, YangM, FanS, DengH, TanT, LiuX, LiuL, LiJ, WangJ, FangX & Feng Y*. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature. 2018. 557(7707):674-678 (highlighted in News and Views in the same issue of Nature)

4.       Huiting E, Cao X, Ren J, Athukoralage J, Luo Z, Silas S, An N, Carion H, Zhou Y, Fraser J, Feng Y*, Bondy-Denomy J*. Bacteriophages inhibit and evade cGAS-like immune function in bacteria. Cell. 2023. 186(4):864-876.e21. (highlighted byTrends Microbiol)

5.       Niu Y, Yang L, Gao T, Dong C, Zhang B, Yin P, Hopp A-K, Li D, Gan R, Wang H, Liu X, Cao X, Xie Y, Meng X, Deng H, Zhang X, Ren J, Hottiger M, Chen Z*, Zhang Y*, Liu X*, Feng Y*. A type I-F anti-CRISPR protein inhibits the CRISPR-Cas Surveillance Complex by ADP-ribosylation. Molecular Cell. 2020. 80(3):512-524 (Lead Contact)

6.       Liu X, Zhang L*, Wang H, Xiu Y, Huang L, Gao Z, Li N, Li F, Xiong W, Gao T, Zhang Y, Yang M*, Feng Y*. Target RNA activates the protease activity of Craspase to confer antiviral defense. Molecular Cell. 2022. (Lead Contact, recommended by F1000 Prime)

7.       Xie Y, Zhang L, Gao Z, Yin P, Wang H, Li H, Chen Z, Zhang Y, Yang M, Feng Y*. AcrIF5 specifically targets DNA-bound CRISPR-Cas Surveillance Complex for inhibition. Nature Chemical Biology. 2022, doi: 10.1038/s41589-022-00995-8

8.       Yang L, Zhang L, Yin P, Ding H, Xiao Y, Zeng J, Wang W, Zhou H, Wang Q, Zhang Y, Chen Z, Yang M, Feng Y*. Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24. Nature Communications. 2022. 13(1):1931

9.       Mu Y, Wang Y, Huang Y, Li D, Han Y, Chang M, Fu J, Xie Y, Ren J, Wang H, Zhang Y, Luo Z, Feng Y*. Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC. Nature Communications. 2020. 11(1):1774

10.     Wang W, Li J, Sun Q, Yu X, Zhang W, Jia N, An C, Li Y, Dong Y, Han F, Chang N, Liu X, Zhu Z, Yu Y, Fan S, Yang M, Luo S, Gao H*, Feng Y*. Structural insights into the coordination of plastid division by the ARC6-PDV2 complex. Nature Plants. 2017 3:17011. (Selected as Hero image article, highlighted in News and Views and commented by Editorial in the same issue of Nature Plants)

11.     Sun Q, Cao X, Liu Z, An C, Hu J, Wang Y, Qiao M, Gao T, Cheng W, Zhang Y, Feng Y*, Gao H*. Structural and functional insights into the chloroplast division site regulators PARC6 and PDV1 in the intermembrane space. PNAS. 2023. 120(5):e2215575120.

12.     Liu X, Zhang L, Xiu Y, Gao T, Huang L, Xie Y, Yang L, Wang W,Wang P*, Zhang Y*, Yang M*, Feng Y*. Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Research. 2021, 49(17):10178-10191.

13.     Gao Z, Zhang L, Ge Z, Wang H, Yue Y, Jiang Z, Wang X, Xu C, Zhang Y*, Yang M*, Feng Y*. Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage. J Biol Chem. 2022, 102575.

14.     Wang H, Gao T, Zhou Y, Ren J, Guo J, Zeng J, Xiao Y, Zhang Y, Feng Y*. Mechanistic insights into the inhibition of the CRISPR-Cas surveillance complex by anti-CRISPR protein AcrIF13. J Biol Chem. 2022, 298(3):101636.

15.     Ren J, Wang H, Yang L, Li F, Wu Y, Luo Z, Chen Z*, Zhang Y*, Feng Y*. Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23. J Biol Chem. 2022, 298(7):102124.


Awards

ª  2020, National Youth Post Expert

ª  2020, Beijing outstanding young talent

ª  2019, Beijing Science and Technology New Star

ª  2019, Excellent Guidance Teacher of undergraduate graduation design of ordinary universities in Beijing

ª  2018, China’s top ten new technolog

ª  2018, Second prize of Beijing Science and Technology Award

ª  2015, Beijing 9th young teachers in colleges and universities teaching basic skills contest


Patent

Honor Reward

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