Chen Long头像

Chen Long

Associate professor

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  • Department: College of Life Science and Technology
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  • Email: chenlong@mail.buct.edu.cn
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  • Introduction
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  • Publications
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  • Honor Reward
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Introduction

Chen Long, Ph.D., Associate Professor at Beijing University of Chemical Technology. He obtained his bachelor's and master's degrees from Tsinghua University in 2004 and 2007, and his doctoral degree from the Stevens Institute of Technology in 2012. Long term commitment to computer-aided and AI assisted molecular design (CADD&AIDD) of medicinal peptides, physicochemical characterization and activity mechanism of medicinal peptides, construction of biological expression systems for medicinal peptides, and fundamental theoretical and technological innovation research related to peptide based drug/nucleic acid delivery systems. Undertook and participated in projects such as the National Natural Science Foundation of China, Beijing Natural Science Foundation, and National Key R&D Program, and published over 40 papers in renowned journals such as ACS Nano, Advanced Science, and Briefing in Bioinformatics. Applied for 7 patents, 2 of which have been authorized. Served as a review expert for the National Natural Science Foundation of China, a review expert for graduate theses from the Ministry of Education. Served as a review editor for Frontiers in Pharmacology. Received awards such as the Young Peptide Scientist Award at the China International Peptide Conference and the Innovation&Entrepreneurship Fellowship at Stevens Institute of Technology.

Education

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Social Activities

Research

Teaching

Postgraduates

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Publications

l Pei P., Chen L. *, Guan X., Wei P., Kang X., Gong L., Liu L., Guo W., Gu R., Wang L., Zhao C., Liang J.F.*, Luo S.Z.* In situ heparan sulfate-induced peptide self-assembly to overcome the cell surface glycocalyx barrier for cancer treatment. ACS Appl. Mater. Interfaces. 2024, 16(37): 49013-49029.

l Pei P., Guo W., Qi M., Jiang J., Feng S., Luo S.Z. and Chen L.* Identification of low-abundance proteins in the royal jelly using the Osborne classification method. J. Proteomics. 2024, 306: 105266.

l Yu X., Duan G., Pei P., Chen L., Gu R., Hu W., Zhang H., Wang Y.D., Gong L., Liu L., Chu T.T., Li J.P., Luo S.Z. Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity. Elife. 2024, 13: RP93871.

l Zhang Y., Qiao Y., Li Z., Liu D., Jin Q., Guo J., Li X., Chen L., Liu L., Peng L. Intestinal NSD2 aggravates nonalcoholic steatohepatitis through histone modifications. Adv. Sci. (Weinh). 2024, 26: e2402551.

l Yu X., Hu W., Dong H., Zhao T., Wang X., Chen L., Xue S., Li J.P., Luo S.Z. Phase separation enhanced PROTAC for highly efficient protein degradation. Biomacromolecules. 2024, 25(7): 4374-4383.

l Ding X., Wang Y., Zhang S., Zhang R., Chen D., Liu C., Xu J.* and Chen L.* Reductive amination of ω-conotoxin MVIIA: synthesis, determination of modification sites, and self-assembly. Amino Acids. 2024, 56(1): 26.

l Zhang X., Xie Y., Huang D., Zhang X., Tang X., Chen L.*, Luo S.Z.*, Lou J.* and He C.* Rapid and mechanically robust immobilization of proteins on silica studied at the single-molecule level by force spectroscopy and verified at the macroscopic level. ACS Appl. Mater. Interfaces. 2024, 16(13): 16962-16972.

l Liu H.N., Wang T., Hu J.J., Chen L., Shi X., Li Y.M. and Luo S.Z. The disordered protein SERF promotes α-synuclein aggregation through liquid-liquid phase separation. J. Biol. Chem. 2024, 300(3): 105667.

l Wang J.#, Chen L.#, Qin S., Xie M., Luo S.Z. and Li W. Advances in biosynthesis of peptide drugs: Technology and industrialization. Biotechnol. J. 2024, 19(1): e2300256.

l Ding X., Wang Y., Zhang S., Zhang R., Chen D., Chen L., Zhang Y., Luo S.Z., Xu J. and Pei C. Self-assembly nanostructure of myristoylated ω-conotoxin MVIIA increases the duration of efficacy and reduces side effects. Mar. Drugs. 2023, 21(4): 229.

l Rui Zhang#, Pengfei Pei#, Yifan Wang, Quanqiang Guo, Shi-Zhong Luo and Long Chen*. A single-chain variable fragment-anticancer lytic peptide (scFv-ACLP) fusion protein for targeted cancer treatment. Chem. Biol. Drug Des. 2023, 101(6): 1406-1415. 

l Pengfei Pei, Long Chen*, Ruru Fan, Xi-Rui Zhou, Shan Feng, Hangrui Liu, Quanqiang Guo, Huiwei Yin, Qiang Zhang, Fude Sun, Liang Peng, Peng Wei, Chengzhi He, Renzhong Qiao, Zai Wang*, Shi-Zhong Luo*. Computer-Aided Design of Lasso-like Self-Assembling Anticancer Peptides with Multiple Functions for Targeted Self-Delivery and Cancer Treatments. ACS Nano. 2022, 16(9): 13783-13799.

l Jialin Chen#, Wujun Wang#, Yue Wang, Xiushuang Yuan, Chengzhi He, Pengfei Pei, Shengdi Su, Weihong Zhao, Shi-Zhong Luo*, Long Chen*. Self-assembling Branched Amphiphilic Peptides for Targeted Delivery of Small Molecule Anticancer Drugs. Eur. J. Pharm. Biopharm. 2022, 179: 137-149.

l Xiushuang Yuan, Shi-Zhong Luo*, Long Chen*. Novel branched amphiphilic peptides for nucleic acids delivery. Int. J. Pharm. 2022, 624: 121983.

l Jialin Chen#, Xiushuang Yuan#, Peng Wei, Daoping Wang, Chen Chen, Quanqiang Guo, Shi-Zhong Luo*, Long Chen*. The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation. Biophys. J. 2022, 121(13): 2613-2623.

l Pengfei Pei#, Hongbo Qin#, Jialin Chen, Fengli Wang, Chengzhi He, Shiting He, Bixia Hong, Ke Liu, Ren-Zhong Qiao, Huahao Fan*, Yi-gang Tong*, Long Chen*, Shi-Zhong Luo*. Computational Design of Ultrashort Peptide Inhibitors of the Receptor Binding Domain (RBD) of the SARS-CoV-2 S protein. Briefings in Bioinformatics. 2021, 22(6): bbab243.

l Yanyan Yuan#, Wujun Wang#, Ruru Fan, Jianhui Jiang*, Shan Feng, Huiwei Yin, Shi-Zhong Luo, Long Chen*. Ethanol-soluble proteins from the royal jelly of Xinjiang black bees. Protein Science. 2021, 30(2): 291-296.

l Yimeng Cao, Huiwei Yin, Wujun Wang, Pengfei Pei, Yin Wang, Xinyu Wang, Jianhui Jiang, Shi-Zhong Luo, Long Chen*. Killing Streptococcus mutans in mature biofilm with a combination of antimicrobial and antibiofilm peptides. Amino Acids. 2020, 52(1): 1-14.

l Long Chen#, Lili Jia#, Qiang Zhang, Xirui Zhou, Zhuqing Liu, Bingjie Li, Zhentai Zhu, Fenwei Wang, Changyuan Yu, Qian Zhang, Feng Chen*, Shi-Zhong Luo*. A novel antimicrobial peptide against dental-caries-associated Bacteria. Anaerobe, 2017, 47: 165-172.

l Fude Sun, Xiufang Ding, Lida Xu, Jun F. Liang, Long Chen* and Shi-Zhong Luo*. A Molecular Dynamics Study of the Short-Helical-Cytolytic Peptide Assembling and Bioactive on Membrane Interface. Journal of Physical Chemistry C. 2017, 121: 17263-17275.

l Fude Sun#, Long Chen#, Xiufang Ding, Lida Xu, Xirui Zhou, Peng Wei, Jun F. Liang* and Shi-Zhong Luo*. High-Resolution Insights into the Stepwise Self-Assembly of Nanofiber from Bioactive Peptides. Journal of Physical Chemistry B. 2017, 121: 7421-7430. 

l Xi-Rui Zhou, Yimeng Cao, Qiang Zhang, Xi-Bo Tian, He Dong, Long Chen*, Shi-Zhong Luo*. Self-assembly nanostructure controlled sustained release, activity and stability of peptide drugs. International Journal of Pharmaceutics. 2017, 528: 723-731. 

l Ruru Fan, Yanyan Yuan, Qiang Zhang, XiRui Zhou, Lili Jia, Zhuqing Liu, Changyuan Yu, ShiZhong Luo*, Long Chen*. Isoleucine/leucine residues at “a” and “d” positions of a heptad repeat sequence are crucial for the cytolytic activity of a short anticancer lytic peptide. Amino Acids. 2017, 49(1): 193-202. 

l Long Chen, Qiang Zhang, Xiushuang Yuan, Yimeng Cao, Yanyan Yuan, Huiwei Yin, Xiufang Ding, Zhentai Zhu, Shi-Zhong Luo. How Charge Distribution Influences the Function of Membrane-active Peptides: Lytic or Cell-Penetrating? International Journal of Biochemistry & Cell Biology, 2017, 83: 71-75.

l X.R. Zhou, Q. Zhang, X.B. Tian, Y.M. Cao, Z.Q. Liu, R. Fan, X.F. Ding, Z. Zhu, L. Chen and S.Z. Luo. From a pro-apoptotic peptide to a lytic peptide: One single residue mutation. Biochim. Biophys. Acta.-Biomembranes. 2016, 1858 (8): 1914-1925. 

l X. Tian, F. Sun, X.R. Zhou, S.Z. Luo* and L. Chen*. Role of peptide self-assembly in antimicrobial peptides. Journal of Peptide Science. 2015, 21(7): 530-539.

l L. Chen and J. F. Liang. The Potential Roles of Cell Surface pHs in Bioactive Peptide Activation. Chemical Biology and Drug Design. 2015, 85(2): 208-215.

l Y. Sun#, L. Chen#, F. Sun, X. Tian and S. Luo. New Amphiphilic N-phosphoryl Oligopeptides Designed for Gene Delivery. International Journal of Pharmaceutics, 2014, 468 (1-2):83-90.

Awards

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