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Copyright@Beijing University of Chemical Technology Address: 15 Beisanhuan East Road, Chaoyang District, Beijing, China Zip code：100029 Email：news@buct.edu.cn |
IntroductionZhang Jianjun, male, Ph.D., associate professor. From 2003 to 2009, he obtained a doctorate in polymer chemistry and physics from the College of Chemistry, Jilin University. From 2007 to 2011, he engaged in joint doctoral training and postdoctoral research at the Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA). In 2011, he joined the High Gravity Engineering Center of the College of Chemical Engineering, Beijing University of Chemical Technology. His main research fields include: molecular structure design of biomedical polymer materials, nano-drug sustained and controlled release technology, and high gravity and supercritical fluid technology. In recent years, the applicant's research group has used high-gravity anti-solvent and supercritical fluid technology, combined with the molecular design of biomedical polymer materials, to prepare a series of anti-tumor and anti-inflammatory nano-drug capsules (docetaxel, doxorubicin, ginsenoside Rh2, minocycline, methotrexate, vancomycin) with high-scale nanometerization, high dissolution rate, and intelligent controlled release. This has expanded the structural design principles and assembly preparation methods of nano-drug preparations, providing a theoretical basis and industrialization support for the preparation of new and efficient nano-drug preparations. Since 2014, the research group has cooperated with relevant enterprises to carry out the design and research and development of medical-grade polylactic acid and its downstream products. At present, the developed products mainly include medical-grade poly-L-lactic acid (PLLA), polycaprolactone (PCL), polylactic acid-glycolic acid (PLGA) raw material products, and a series of research and development products such as PLLA microparticle soft tissue filling powder injection, PLLA filling gel, and PLLA/hyaluronic acid microneedle. To date, as the project leader and main researcher, I have participated in a total of 7 national-level vertical scientific research projects such as the National Natural Science Foundation of China, the Ministry of Science and Technology's 863 and 973 projects, and other provincial and ministerial-level projects, and 5 horizontal technology development projects for enterprises and scientific research institutions; applied for 10 national invention patents and 3 have been authorized; published more than 20 research papers, and many papers have been published in international academic journals such as Advanced Materials, Biomacromolecules, and Nano Research. EducationWork ExperienceSocial PositionSocial ActivitiesResearchØ Structure design and performance study of smart anti-cancer drug nanocapsules. Ø Preparation of functional nanodrugs and drug delivery microspheres by high-gravity anti-solvent techniques. Ø Design and synthesis of biocompatible and biodegradable polymer materials and its applications in tissue engineering. Ø Design and synthesis of injectable hydrogels and its applications in drug delivery and stem cell transplantation. TeachingPostgraduatesFunding1.“Glucose-triggered reactive oxygen species/acidic dual-responsive organic/inorganic nanocomposite hydrogels for combination therapy of diabetic severe periodontitis”. Agency: National Natural Science Foundation of China (NSFC). Grant: 52072023. Role: PI. Period: 01/2020-12/2023. 2.“Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Combined with Nano-hydroxyapatite Enhanced Sodium Alginate/Hyaluronic Acid Hydrogel for Bone Regeneration”. Agency: National Natural Science Foundation of China (NSFC). Grant: 51972339. Role: Co-I. Period: 01/2019-12/2022. 3.“Structure design and performance study of anti-cancer nanocapsules with double-smart layers”. Agency: National Natural Science Foundation of China (NSFC). Grant: 21476018. Role: PI. Period: 01/2015-12/2018. 4. “Molecular designing, high gravity preparation and application of PLA-based multifunctional nanodrugs for anti-cancer drug delivery”. Agency: National Natural Science Foundation of China (NSFC). Grant: 51303009. Role: PI. Period: 01/2014-12/2016. 5. National Key R&D Program of China. Grant: 2015CB932101. Role: Co-I. Period: 01/2015-12/2018. 6. National 863 Program of China. Grant: 2013AA032201. Role: Co-I. Period: 01/2013-12/2016. Vertical ProjectHorizontal ProjectPublications1. Shuo Yang, Biao Zhu, Peng Yin, Lisheng Zhao, Yizhu Wang, Zhiguang Fu, Ruijie Dang, Juan Xu*, Jianjun Zhang*, and Ning Wen*, Integration of Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes with Hydroxyapatite-Embedded Hyaluronic Acid-Alginate Hydrogel for Bone Regeneration, ACS Biomater. Sci. Eng., 2020, 6, 1590−1602. 2. Jie Liu, Bo Chen*, Jianjun Zhang*, Preparation of pH-Responsive Doxorubicin Nanocapsules by Combining High-gravity Antisolvent Precipitation with In-situ Polymerization for Intracellular Anticancer Drug Delivery, Chem. Res. Chin. Univ., 2020, doi: 10.1007/s40242-020-0007-4. 3. Wei Li, Cheng Tao, Jiexin Wang*, Yuan Le, Jianjun Zhang*, MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma, RSC Adv., 2019, 9, 31264–31273. 4. Zhenzhen Ma, Cheng Tao2, Lin Sun, Shengbei Qi, Yuan Le, Jiexin Wang, Changhong Li, Xiangyuan Liu, Jianjun Zhang*, Jinxia Zhao*, In Situ Forming Injectable Hydrogel for Encapsulation of Nanoiguratimod and Sustained Release Of Therapeutics, International Journal of Nanomedicine, 2019:14 8725–8738. 5. Huanhuan Wang#, Zhiguang Fu#, Wei Li, Yunxia Li, Lisheng Zhao, Li Wen, Jianjun Zhang*, Ning Wen*. The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell. International Journal of Nanomedicine, 2019(14):623-638. 6．Xiaoqing Song, Cheng Tao, Wei Li, Jiexin Wang, Yuan Le* and Jianjun Zhang*. Preparation of Reduction-Responsive Camptothecin Nanocapsules by Combining Nanoprecipitation and In Situ Polymerization for Anticancer Therapy. Pharmaceutics, 2018, 10, 173. 7.Yunxia Li, Wenjuan Du, Zhiguang Fu, Huanhuan Wang, Jiexin Wang, Yuan Le, Jianjun Zhang*, Ning Wen*. pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery. Chem. Res. Chin. Univ., 2018, 34(6):1041-1050. 8. Cheng Tao, Jianjun Zhang*, Jiexin Wang, Yuan Le*. Ginsenoside Drug Nanocomposites Prepared by the Aerosol Solvent Extraction System for Enhancing Drug Solubility and Stability. Pharmaceutics, 2018,10(3):95. 9. Jianjun Zhang*, Yunxia Li, Jiexin Wang, Shengpei Qi, Xiaoqing Song, Cheng Tao, Yuan Le, Ning Wen, Jianfeng Chen. Dual redox-responsive PEG–PPS–cRGD self-crosslinked nanocapsules for targeted chemotherapy of squamous cell carcinoma. RSC Advances, 2017, 7(84):53552-53562. 10. Wei Teng, Jiexin Wang, Neil T Foster, Jianfeng Chen, Ning Wen, Jianjun Zhang*, Preparation of Silybin/Poly(vinylpyrrolidone) Nanodrugs by Using the Aerosol Solvent Extraction System for Improving Drug Solubility, Industrial & Engineering Chemistry Research, 2014, 53, 10519. 11. Ruiduan Li, Jianjun Zhang*, Jianfeng Chen*, Wei Teng, Jiexin Wang, Caixia Li, Preparation and Characterization of Biological Non-toxic Hybrid Nanoparticles Based on Lactide and Poly(ethylene glycol) Loading Docetaxel for Anticancer Drug Delivery, Chinese Journal of Chemical Engineering, 2014, 22, 1057. 12. Zheng Wang, Jianjun Zhang*, Ruiduan Li, Jianfeng Chen, Synthesis of Cationic Magnetite Nanoparticles for Intracellular Protein Delivery, Journal of Applied Polymer Science, 2014, 131, 40260. 13. Jianjun Zhang*, Ge Gao, Fengqi Liu, Jianfeng Chen. Preparation of PS/MEH-PPV Fluorescent Microspheres by Miniemulsion Polymerization. Polymer International, 2013, 62,665. 14. Jianjun Zhang*, Ge Gao, Fengqi Liu, Preparation of Zinc Oxide Nanocrystals with High Stability in the Aqueous Phase. Journal of Applied Polymer Science, 2013, 2162. 15. Jianjun Zhang, Jin Zhong and Tatiana Segura, “Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation”, Advanced Materials, 2011, 23, 5098. 16. Jianjun Zhang, Yuguo Lei, Juanjuan Du, Ming Yan, Tatiana Segura*, Yunfeng Lu. Protein-polymer nanoparticles for non-viral gene delivery. Biomacromolecules, 2011, 12, 1006. 17. Jianjun Zhang, Juanjuan Du, Ming Yan, Yunfeng Lu*, Fengqi Liu. Synthesis of Protein Nano-Conjugates for Cancer Therapy. Nano Research, 2011, 4, 425. AwardsPatentHonor RewardAdmissions Information |